Q07WH1 · LEUC_SHEFN
- Protein3-isopropylmalate dehydratase large subunit
- GeneleuC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids470 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Catalytic activity
- (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway
Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3-isopropylmalate dehydratase activity | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | metal ion binding | |
Biological Process | L-leucine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-isopropylmalate dehydratase large subunit
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Shewanellaceae > Shewanella
Accessions
- Primary accessionQ07WH1
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000319840 | 1-470 | 3-isopropylmalate dehydratase large subunit | |||
Sequence: MAQVTGKTLYEKVWDSHIVASPEGEAPVVYVDRHLVHEVTSPQAFSGLKVAGRKLRAPQKTFATMDHNTSTRSASLDALSPMARTQVETLAQNCKEFGVRLYDIHHPNQGIVHVMGPELGITLPGTVIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLRQLKAKNMKVEVRGKVTDGVTAKDIVLAIIGKLGMDGGTGYVVEFCGEAIEALTMEGRMTLCNMAIEMGAKAGMVAPDETTFNYLKGREFAPKDAMWEQAVAAWSELKSDADAVFDVEVVLDANDIAPQLTWGTNPGQVVAIDGVVPNPETETNSTNRTSMIKALEYIGLTPGTKMTDISINKVFIGSCTNSRIEDLRSAAVHAKNRKVAEGVVAIVVPGSGQVKLQAEEEGLDKIFIEAGFEWRLPGCSMCLAMNDDRLDAGDRCASTSNRNFEGRQGRGSRTHLVSPAMAAAAAVAGHFVDIRKPY |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length470
- Mass (Da)50,381
- Last updated2006-10-31 v1
- Checksum24F96E0E8768A9E2
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000447 EMBL· GenBank· DDBJ | ABI73643.1 EMBL· GenBank· DDBJ | Genomic DNA |