Q06576 · HP25_TAMSI
- ProteinHibernation-associated plasma protein HP-25
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids215 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Plasma proteins HP-20, HP-25, HP-27 and HP-55 form a 140 kDa complex via disulfide bonds in the plasma and are hibernation specific.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | collagen trimer | |
Cellular Component | extracellular region | |
Biological Process | hibernation |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameHibernation-associated plasma protein HP-25
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Sciuromorpha > Sciuridae > Xerinae > Marmotini > Tamias
Accessions
- Primary accessionQ06576
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-28 | |||||
Sequence: MPAQRGGALSMGAAGFWILVLSITSALA | ||||||
Chain | PRO_0000003559 | 29-215 | Hibernation-associated plasma protein HP-25 | |||
Sequence: DSNNQGNSEPCGPPGPPGPPGIPGFPGAPGALGPPGPPGVPGIPGPQGPPGDVEKCSSRPKSAFAVKLSERPPEPFQPIVFKEALYNQEGHFNMATGEFSCVLPGVYNFGFDIRLFQSSVKIRLMRDGIQVREKEAQANDSYKHAMGSVIMALGKGDKVWLESKLKGTESEKGITHIVFFGYLLYGK | ||||||
Glycosylation | 167 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Expression
Tissue specificity
Plasma; synthesized in the liver.
Developmental stage
The protein complex disappears from the plasma at onset of hibernation and reappears as hibernation ceases.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 29-96 | Disordered | ||||
Sequence: DSNNQGNSEPCGPPGPPGPPGIPGFPGAPGALGPPGPPGVPGIPGPQGPPGDVEKCSSRPKSAFAVKL | ||||||
Compositional bias | 38-76 | Pro residues | ||||
Sequence: PCGPPGPPGPPGIPGFPGAPGALGPPGPPGVPGIPGPQG | ||||||
Domain | 40-81 | Collagen-like | ||||
Sequence: GPPGPPGPPGIPGFPGAPGALGPPGPPGVPGIPGPQGPPGDV | ||||||
Domain | 85-215 | C1q | ||||
Sequence: SSRPKSAFAVKLSERPPEPFQPIVFKEALYNQEGHFNMATGEFSCVLPGVYNFGFDIRLFQSSVKIRLMRDGIQVREKEAQANDSYKHAMGSVIMALGKGDKVWLESKLKGTESEKGITHIVFFGYLLYGK |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length215
- Mass (Da)22,664
- Last updated1995-11-01 v1
- ChecksumAFE03206917EA530
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 38-76 | Pro residues | ||||
Sequence: PCGPPGPPGPPGIPGFPGAPGALGPPGPPGVPGIPGPQG |
Keywords
- Technical term