Q04669 · MOUB_ORNMO

Function

function

Tick salivary platelet aggregation inhibitor that plays an important part in the anti-hemostatic strategy of ticks. Acts by scavenging thromboxane A2 (TXA2), a potent inducer of platelet aggregation and blood vessel constriction (PubMed:18694828, PubMed:8449906).
As a consequence, is a specific inhibitor of collagen-induced platelet aggregation (PubMed:8449906, PubMed:8449907).
In addition, it also acts as a potent inhibitor of TXA2-mediated vasoconstriction (PubMed:18694828).
Has also been found to bind leukotriene B4 (LTB4) (which also derives from arachidonic acid, as TXA2) with affinities in the nanomolar range (PubMed:18694828).
It does not interact with complement protein C5 (PubMed:18694828).

Caution

There are 10 AA differences between the cDNA deduced sequence and the determined protein sequence. These differences are not indicated in the paper.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functiontoxin activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Moubatin
  • Alternative names
    • Lipocalin
    • Platelet aggregation inhibitor
      (PAI
      )

Organism names

Accessions

  • Primary accession
    Q04669

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-15
ChainPRO_000002173216-171Moubatin
Disulfide bond23↔144
Disulfide bond55↔166
Disulfide bond118↔145

Post-translational modification

The N-terminus is blocked.

Keywords

Expression

Tissue specificity

Expressed in salivary glands.

Structure

Family & Domains

Sequence similarities

Belongs to the calycin superfamily. Lipocalin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    171
  • Mass (Da)
    18,824
  • Last updated
    1994-02-01 v1
  • Checksum
    79EC7B7E460FA74B
MMLVLTTLIFSFSASIAYAQSGCSVSDPLDALKAFKDGAGTFLLQKSTDPQARDCLKGTPNGNRDGNTLPVTMTYKDDSKWVSLNWMFTLEGANIVATLEGKRKQRGELVYDVQSHDCHITKLSSGVYQQWQSNGSADDKDIKCCDEKFKELTSGIDYTKPQEKGCETSAK

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict54in Ref. 1; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L04129
EMBL· GenBank· DDBJ
AAA29432.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp