P96178 · RPOC_WEIPA

Function

function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 Zn2+ ion1 per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site383Mg2+ (UniProtKB | ChEBI)
Binding site385Mg2+ (UniProtKB | ChEBI)
Binding site387Mg2+ (UniProtKB | ChEBI)
Binding site752Zn2+ (UniProtKB | ChEBI)
Binding site826Zn2+ (UniProtKB | ChEBI)
Binding site833Zn2+ (UniProtKB | ChEBI)
Binding site836Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentDNA-directed RNA polymerase complex
Molecular FunctionDNA binding
Molecular FunctionDNA-directed 5'-3' RNA polymerase activity
Molecular Functionmetal ion binding
Biological ProcessDNA-templated transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA-directed RNA polymerase subunit beta'
  • EC number
  • Short names
    RNAP subunit beta'
  • Alternative names
    • RNA polymerase subunit beta'
    • Transcriptase subunit beta'

Gene names

    • Name
      rpoC

Organism names

Accessions

  • Primary accession
    P96178

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000678321-1054DNA-directed RNA polymerase subunit beta'

Interaction

Subunit

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

Structure

Family & Domains

Sequence similarities

Belongs to the RNA polymerase beta' chain family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    1,054
  • Mass (Da)
    118,067
  • Last updated
    1997-05-01 v1
  • Checksum
    1B3E81C060154EEA
RIRYKGIVCDRCGVEVTSAKVRRERMGHIELAAPVSHIWYFKGIPSRMGLVLDMSPRSLEEIIYFASYVVTKGGDTPLTEKQLLSEREYRELKAEYGNAFEAGMGAEAVQTLLANVDLEEEVTELKAELREATGQKRVRAVRRLDIIEAFVKSGNKPEWMVMDVIPIIPPDLRPMVQLEGGRFATSDLNDLYRRVINRNNRLKRLLELNAPGIIVQNEKRMLQEAADALVDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIDVGPFLKMNQMGLPRQMAMELFRPFIMKELVKRDLAGNIRAAKRKIDRRDDDVMDVLEDVIKEHPVLLNRAPTLHRLGIQAFEPVLVSGKAMRLHPLVTEAYNADFDGDQMAIHVPLSDEAQAEARLLMLAAGHILAPKDGKPIVAPSQDMVIGNYYLTTEEAGREGEGMIFKDVNEVRTAYQNKYVHLHTRIGIQTSSLPAAKPFTAEQRSRIMLTSVGKLFFNDILPEDFPFLNEPTEANLHEIDNRFFLEPGEDIKAHYAETPILPPFKKGYLSDIIAEVYKIYKVTETSLLLDRMKDLGYDESTKSGLTVGVSDVTDLKEKPEIIADAHKQVATVTKQFRRGLITDSERYERVIAIWNKAKDDITEKLIEHFEPDNNIFMMSDSGARGNISNFTQLAGMRGLMAAPNGRIMELPIIANFREGLSVLEMFFSTHGARKGMTDTALKTADSGYMTRRLVDVAQDVIIRELDCHSDRGLDVTAIMNGNEVIEPLYERILGRYAQKSVFDPETGETLVNHNEMITEDIAKRIIEAGITTVTIRSAFTCNTEHGVCVRCYGRNMATGDVVEVGEAVGTVAAQSIGEPGTQLTMRTFHTGGVAGNDITQGLPRVQEIFEARNPKGRAMITEVTGEVTSIEENPADRTKEVTIQGETDTRTYTLPMTARMRVGEGDRIHRGETLNEGSADPKEIIQVRDTLATENYIVHEVQKVYRMQGVEISDKHIEVMARQMLRKVRVMDPGETDLLPGTLMDIAQFRDANEDTLLKGGLPATGRPV

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue1054

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X95813
EMBL· GenBank· DDBJ
CAA65080.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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