P96050 · FOLD_STRTR

Function

function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Catalytic activity

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site165-167NADP+ (UniProtKB | ChEBI)
Binding site190NADP+ (UniProtKB | ChEBI)
Binding site231NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmethenyltetrahydrofolate cyclohydrolase activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological ProcessL-histidine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processpurine nucleotide biosynthetic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein FolD

Including 2 domains:

  • Recommended name
    Methylenetetrahydrofolate dehydrogenase
  • EC number
  • Recommended name
    Methenyltetrahydrofolate cyclohydrolase
  • EC number

Gene names

    • Name
      folD

Organism names

Accessions

  • Primary accession
    P96050

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001993171-284Bifunctional protein FolD

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    284
  • Mass (Da)
    31,383
  • Last updated
    1997-05-01 v1
  • Checksum
    B23ED2124377AF88
MAIIMDGKALAVNMQEQLQEKVARLKEKEWIVPGLVVIMVGENPASQVYVRNKERAAKKAGFHSKTVNLSESISEEELIEVIEKYNQNPLFHGILVQLPLPNHINEMRILLAIDPKKDVDGFHPMNTGNLWNGRPQMVPCTPAGIMEILREYNVELEGKTAVIIGRSNIVGKPMAQLLLEKNATVTLTHSRTPHLAKVCNKADVLIVAIGRAKFVTEEFVKEGAVVIDVGINRDEEGKLCGDVDFDQVKEKVSMITPVPGGVGPMTITMLMEQTYQAALRSLKG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U58210
EMBL· GenBank· DDBJ
AAC44612.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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