P96050 · FOLD_STRTR
- ProteinBifunctional protein FolD
- GenefolD
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids284 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Catalytic activity
- (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP+ = (6R)-5,10-methenyltetrahydrofolate + NADPH
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | methenyltetrahydrofolate cyclohydrolase activity | |
Molecular Function | methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
Biological Process | L-histidine biosynthetic process | |
Biological Process | methionine biosynthetic process | |
Biological Process | purine nucleotide biosynthetic process | |
Biological Process | tetrahydrofolate interconversion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional protein FolD
Including 2 domains:
- Recommended nameMethylenetetrahydrofolate dehydrogenase
- EC number
- Recommended nameMethenyltetrahydrofolate cyclohydrolase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionP96050
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000199317 | 1-284 | Bifunctional protein FolD | |||
Sequence: MAIIMDGKALAVNMQEQLQEKVARLKEKEWIVPGLVVIMVGENPASQVYVRNKERAAKKAGFHSKTVNLSESISEEELIEVIEKYNQNPLFHGILVQLPLPNHINEMRILLAIDPKKDVDGFHPMNTGNLWNGRPQMVPCTPAGIMEILREYNVELEGKTAVIIGRSNIVGKPMAQLLLEKNATVTLTHSRTPHLAKVCNKADVLIVAIGRAKFVTEEFVKEGAVVIDVGINRDEEGKLCGDVDFDQVKEKVSMITPVPGGVGPMTITMLMEQTYQAALRSLKG |
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length284
- Mass (Da)31,383
- Last updated1997-05-01 v1
- ChecksumB23ED2124377AF88
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U58210 EMBL· GenBank· DDBJ | AAC44612.1 EMBL· GenBank· DDBJ | Genomic DNA |