P92845 · CYB_AGKCO

Function

function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

Miscellaneous

Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.

Caution

The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 2 heme b groups non-covalently.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site81Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site95Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site180Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site194Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site199a ubiquinone (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex III
Molecular Functionmetal ion binding
Molecular Functionubiquinol-cytochrome-c reductase activity
Biological Processmitochondrial electron transport, ubiquinol to cytochrome c

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b
  • Alternative names
    • Complex III subunit 3
    • Complex III subunit III
    • Cytochrome b-c1 complex subunit 3
    • Ubiquinol-cytochrome-c reductase complex cytochrome b subunit

Gene names

    • Name
      MT-CYB
    • Synonyms
      COB, CYTB, MTCYB

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Viperidae > Crotalinae > Agkistrodon

Accessions

  • Primary accession
    P92845
  • Secondary accessions
    • Q9ZZ66

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane31-51Helical
Transmembrane75-96Helical
Transmembrane111-131Helical
Transmembrane176-196Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000605361-214Cytochrome b

Interaction

Subunit

The cytochrome bc1 complex contains 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and probably 6 low-molecular weight proteins.

Structure

Family & Domains

Sequence similarities

Belongs to the cytochrome b family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    214
  • Mass (Da)
    24,168
  • Last updated
    2000-05-30 v2
  • Checksum
    8F98E544B7E39B68
YINYKNMSHQHMLTLFNLLPVGSNISIWWNFGSMLLTCLMIQIATGFFLAIHYTANINLAFSSIIHISRDVPYGWIMQNTHAIGASLFFICIYIHIARGIYYGSYLNKEVWLSGTTLLIILMATAFFGYVLPWGQMSFWAATVITNLLTAIPYLGTTLTTWLWGGYAINDPTLTRFFALHFILPFAIISMSSIHILLLHNEGSNNPLGTNSDID

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue214

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF039268
EMBL· GenBank· DDBJ
AAC33545.1
EMBL· GenBank· DDBJ
Genomic DNA
U96022
EMBL· GenBank· DDBJ
AAC24738.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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