P86867 · OSTC1_DIPSG

Function

function

The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein (By similarity).
The carboxylated form binds strongly to apatite and calcium (By similarity).

Features

Showing features for binding site.

14551015202530354045
AAGQLSLTQLESLREVCELNLACEHMMDTEGIIAAYTAYYGPIPY
TypeIDPosition(s)Description
Binding site11Ca2+ 1 (UniProtKB | ChEBI)
Binding site15Ca2+ 2 (UniProtKB | ChEBI)
Binding site18Ca2+ 2 (UniProtKB | ChEBI)
Binding site18Ca2+ 3 (UniProtKB | ChEBI)
Binding site24Ca2+ 3 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functioncalcium ion binding
Molecular Functionhormone activity
Molecular Functionhydroxyapatite binding
Molecular Functionstructural constituent of bone
Biological Processbiomineral tissue development
Biological Processbone development
Biological Processcellular response to insulin stimulus
Biological Processglucose homeostasis
Biological Processnegative regulation of bone development
Biological Processosteoblast differentiation
Biological Processregulation of cellular response to insulin stimulus
Biological Processresponse to vitamin K
Biological Processtype B pancreatic cell proliferation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Osteocalcin 1
  • Short names
    DsaOC1
  • Alternative names
    • Bone Gla protein
      (BGP
      )
    • Gamma-carboxyglutamic acid-containing protein

Gene names

    • Name
      bglap

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Spariformes > Sparidae > Diplodus

Accessions

  • Primary accession
    P86867

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00004369191-45Osteocalcin 1
Modified residue114-carboxyglutamate
Modified residue154-carboxyglutamate
Disulfide bond17↔23
Modified residue184-carboxyglutamate

Post-translational modification

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation by GGCX. These residues are essential for the binding of calcium.

Keywords

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-41Gla

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    45
  • Mass (Da)
    4,951
  • Last updated
    2016-09-07 v1
  • Checksum
    5BAEE6A1D0CB4A18
AAGQLSLTQLESLREVCELNLACEHMMDTEGIIAAYTAYYGPIPY

Keywords

Similar Proteins

Disclaimer

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