P85281 · NDKB_MERCP
- ProteinNucleoside diphosphate kinase B
- Genenme2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids126 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Major role in the synthesis of nucleoside triphosphates other than ATP.
Catalytic activity
- a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 6 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 37 | ATP (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 68 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 79 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 89 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Active site | 92 | Pros-phosphohistidine intermediate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | lamellipodium | |
Cellular Component | nucleus | |
Cellular Component | ruffle | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | nucleoside diphosphate kinase activity | |
Biological Process | CTP biosynthetic process | |
Biological Process | GTP biosynthetic process | |
Biological Process | UTP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNucleoside diphosphate kinase B
- EC number
- Short namesNDK B; NDP kinase B
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Zeiogadaria > Gadariae > Gadiformes > Gadoidei > Merlucciidae > Merluccius
Accessions
- Primary accessionP85281
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000306187 | 1-126 | Nucleoside diphosphate kinase B | |||
Sequence: TFVAIKPDGVQRGLCGEVMKFIQPMKQHYLDLKDMPFYAGLCKYMSSGPVFAMVWEGEGIVKMMLGETNPADSKPGSIRGDFCINIGRNIIHGSDTVENAKMEVALWFKPEEFVTYTEKAKAWVYE |
Keywords
- PTM
Structure
Sequence
- Sequence statusFragments
- Length126
- Mass (Da)14,207
- Last updated2007-10-02 v1
- Checksum619C9DBA188274CC
Features
Showing features for non-terminal residue, non-adjacent residues.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: T | ||||||
Non-adjacent residues | 20-21 | |||||
Sequence: KF | ||||||
Non-adjacent residues | 24-25 | |||||
Sequence: PM | ||||||
Non-adjacent residues | 62-63 | |||||
Sequence: KM |
Keywords
- Technical term