P83943 · DEFB1_CHILA

Function

function

Has antibacterial activity against Gram-positive bacterium S.pneumoniae Serotype 14. Is also active against Gram-negative bacteria M.catarrhalis 1857, and non-typeable H.influenzae strains 86-028NP and 1128. Has antifungal activity against C.albicans. May have a role in maintaining sterility in the middle ear (PubMed:14996845).
May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Cellular Componentmembrane
Cellular Componentmicrovesicle
Cellular Componentsperm midpiece
Molecular FunctionCCR6 chemokine receptor binding
Molecular Functionchemoattractant activity
Molecular Functionidentical protein binding
Biological Processcalcium-mediated signaling
Biological Processcell chemotaxis
Biological Processdefense response to fungus
Biological Processdefense response to Gram-negative bacterium
Biological Processdefense response to Gram-positive bacterium
Biological Processkilling by host of symbiont cells
Biological Processpositive regulation of flagellated sperm motility involved in capacitation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Beta-defensin 1
  • Short names
    BD-1
  • Alternative names
    • Defensin, beta 1
    • cBD-1

Gene names

    • Name
      DEFB1

Organism names

Accessions

  • Primary accession
    P83943

Proteomes

Subcellular Location

Secreted
Membrane
Note: Associates with tumor cell membrane-derived microvesicles.

Keywords

PTM/Processing

Features

Showing features for signal, peptide, disulfide bond.

TypeIDPosition(s)Description
Signal1-22
PeptidePRO_000000689623-67Beta-defensin 1
Disulfide bond33↔62
Disulfide bond40↔55
Disulfide bond45↔63

Keywords

Expression

Tissue specificity

Highly expressed in tongue, nasopharyngeal mucosa and skin, and to a lower extent in the Eustachian tube, lung and trachea.

Interaction

Subunit

Monomer. Homodimer.

Structure

Family & Domains

Sequence similarities

Belongs to the beta-defensin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    67
  • Mass (Da)
    7,676
  • Last updated
    2004-06-07 v1
  • Checksum
    30A611CDCCD5BA8D
MRIHYLLFAVLFLFLMPVPGEGGIINTIQRYFCRVRGGRCAALTCLPRETQIGRCSVKGRKCCRTRK

Mass Spectrometry

Molecular mass is 5,123 Da. Determined by Electrospray.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY128668
EMBL· GenBank· DDBJ
AAM97293.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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