P81204 · NUC1_SYNRA

Function

function

This enzyme has both RNase and DNase activity.

Miscellaneous

The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for active site, binding site.

132050100150200250300
TypeIDPosition(s)Description
Active site155Proton acceptor
Binding site187Mg2+ (UniProtKB | ChEBI); catalytic

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentmitochondrial inner membrane
Cellular Componentnucleus
Molecular Functionmetal ion binding
Molecular Functionnucleic acid binding
Molecular FunctionRNA endonuclease activity
Molecular Functionsingle-stranded DNA endodeoxyribonuclease activity
Biological Processapoptotic DNA fragmentation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nuclease
  • EC number
  • Alternative names
    • Sr-nuclease

Organism names

Accessions

  • Primary accession
    P81204
  • Secondary accessions
    • Q9UVC4

Subcellular Location

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis155Loss of activity.

PTM/Processing

Features

Showing features for propeptide, signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
PropeptidePRO_0000019922?-70
Signal1-?
ChainPRO_000001992371-320Nuclease
Glycosylation204N-linked (GlcNAc...) asparagine
Disulfide bond312↔317

Post-translational modification

Glycosylated.

Keywords

PTM databases

Interaction

Subunit

Homodimer; as a result of non-covalent interactions and not through the disulfide linkages between the two monomers.

Structure

Family & Domains

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    320
  • Mass (Da)
    35,316
  • Last updated
    1999-07-15 v1
  • Checksum
    9C29F093ABB7A7DE
MPIIRRTSRATASSSKSATSSILRQAILVFTGFLLGALFMVFVPSLYNAAEPSSLHRLMNPIRRNTLSARASSDILKLGNPGPVSDLLERSGYILSYNRRDRLAHWVGEHLTSASLQAGQGVDRDKSNFQEDTDIPEMFRAHLKDYVSSGYDRGHQAPAADDLSSQEAMDETFLLSNMAPQVGVGFNRHYWAYLEGFMRDLTQNFTDVYVYTGPLFLPSAASTGRKNPAYSIEYPFLGATTPNVPVPTHFFKIALTTTASSEYALGAFVLPNQAIDSSTPLTNFKVELEAIEKAAGLVFFDKLDRSKFADLCSKTTCQVR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF043515
EMBL· GenBank· DDBJ
AAC69516.1
EMBL· GenBank· DDBJ
mRNA
AF043727
EMBL· GenBank· DDBJ
AAF21658.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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