P81204 · NUC1_SYNRA
- ProteinNuclease
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids320 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
This enzyme has both RNase and DNase activity.
Miscellaneous
The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules.
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Features
Showing features for active site, binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | mitochondrial inner membrane | |
Cellular Component | nucleus | |
Molecular Function | metal ion binding | |
Molecular Function | nucleic acid binding | |
Molecular Function | RNA endonuclease activity | |
Molecular Function | single-stranded DNA endodeoxyribonuclease activity | |
Biological Process | apoptotic DNA fragmentation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNuclease
- EC number
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Mucoromycotina > Mucoromycetes > Mucorales > Syncephalastraceae > Syncephalastrum
Accessions
- Primary accessionP81204
- Secondary accessions
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 155 | Loss of activity. | ||||
Sequence: H → A |
PTM/Processing
Features
Showing features for propeptide, signal, chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Propeptide | PRO_0000019922 | ?-70 | ||||
Sequence: MPIIRRTSRATASSSKSATSSILRQAILVFTGFLLGALFMVFVPSLYNAAEPSSLHRLMNPIRRNTLSAR | ||||||
Signal | 1-? | |||||
Chain | PRO_0000019923 | 71-320 | Nuclease | |||
Sequence: ASSDILKLGNPGPVSDLLERSGYILSYNRRDRLAHWVGEHLTSASLQAGQGVDRDKSNFQEDTDIPEMFRAHLKDYVSSGYDRGHQAPAADDLSSQEAMDETFLLSNMAPQVGVGFNRHYWAYLEGFMRDLTQNFTDVYVYTGPLFLPSAASTGRKNPAYSIEYPFLGATTPNVPVPTHFFKIALTTTASSEYALGAFVLPNQAIDSSTPLTNFKVELEAIEKAAGLVFFDKLDRSKFADLCSKTTCQVR | ||||||
Glycosylation | 204 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 312↔317 | |||||
Sequence: CSKTTC |
Post-translational modification
Glycosylated.
Keywords
- PTM
PTM databases
Interaction
Subunit
Homodimer; as a result of non-covalent interactions and not through the disulfide linkages between the two monomers.
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length320
- Mass (Da)35,316
- Last updated1999-07-15 v1
- Checksum9C29F093ABB7A7DE
Keywords
- Technical term