P68258 · HBG2_CEBAL

Function

function

Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.

Features

Showing features for binding site.

114720406080100120140
TypeIDPosition(s)Description
Binding site64Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); distal binding residue
Binding site93Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); proximal binding residue

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentblood microparticle
Cellular Componenthaptoglobin-hemoglobin complex
Cellular Componenthemoglobin complex
Molecular Functionhaptoglobin binding
Molecular Functionheme binding
Molecular Functionhemoglobin alpha binding
Molecular Functionmetal ion binding
Molecular Functionorganic acid binding
Molecular Functionoxygen binding
Molecular Functionoxygen carrier activity
Molecular Functionperoxidase activity
Biological Processhydrogen peroxide catabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Hemoglobin subunit gamma-2
  • Alternative names
    • Gamma-2-globin
    • Hemoglobin gamma-2 chain

Gene names

    • Name
      HBG2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Platyrrhini > Cebidae > Cebinae > Cebus

Accessions

  • Primary accession
    P68258
  • Secondary accessions
    • Q28225
    • Q29434

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000532431-147Hemoglobin subunit gamma-2
Modified residue13Phosphothreonine
Modified residue45Phosphoserine
Modified residue51Phosphoserine
Modified residue53Phosphoserine
Modified residue60N6-acetyllysine
Modified residue83N6-acetyllysine
Modified residue94S-nitrosocysteine
Modified residue140Phosphoserine
Modified residue144Phosphoserine

Keywords

Expression

Tissue specificity

Red blood cells.

Interaction

Subunit

Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F).

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-147Globin

Sequence similarities

Belongs to the globin family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    147
  • Mass (Da)
    15,936
  • Last updated
    2007-01-23 v2
  • Checksum
    8A7CB81F98E85D03
MSNFTAEDKAAITSLWAKVNVEDAGGETLGRLLVVYPWTQRFFDSFGSLSSPSAIMGNPKVKAHGAKVLTSLGEAIKNLDDLKGTFGQLSELHCDKLHVDPENFRLLGNVLVTVLAIHHGKEFTPEVQASWQKMVAGVASALGSRYH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M81409
EMBL· GenBank· DDBJ
AAA19704.1
EMBL· GenBank· DDBJ
Unassigned DNA

Similar Proteins

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