P59265 · PA2BB_PROFL
- ProteinBasic phospholipase A2 PLA-B
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids122 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Snake venom phospholipase A2 (PLA2) that displays edema-inducing activities. PLA-B is three times more active than PLA-A in edema-inducing activities. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+
Cofactor
Note: Binds 1 Ca2+ ion.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | calcium ion binding | |
Molecular Function | calcium-dependent phospholipase A2 activity | |
Molecular Function | phospholipid binding | |
Molecular Function | toxin activity | |
Biological Process | arachidonic acid secretion | |
Biological Process | lipid catabolic process | |
Biological Process | phospholipid metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBasic phospholipase A2 PLA-B
- EC number
- Short namessvPLA2
- Alternative names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Viperidae > Crotalinae > Protobothrops
Accessions
- Primary accessionP59265
Subcellular Location
PTM/Processing
Features
Showing features for chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000161700 | 1-122 | Basic phospholipase A2 PLA-B | |||
Sequence: HLLQFRKMIKKMTGKEPIVSYAFYGCYCGKGGRGKPKDATDRCCFVHDCCYEKVTGCDPKWSYYTYSLENGDIVCEGDPYCTKVKCECDKKAAICFRDNLKTYKNRYMTFPDIFCTDPTEGC | ||||||
Disulfide bond | 26↔115 | |||||
Sequence: CYCGKGGRGKPKDATDRCCFVHDCCYEKVTGCDPKWSYYTYSLENGDIVCEGDPYCTKVKCECDKKAAICFRDNLKTYKNRYMTFPDIFC | ||||||
Disulfide bond | 28↔44 | |||||
Sequence: CGKGGRGKPKDATDRCC | ||||||
Disulfide bond | 43↔95 | |||||
Sequence: CCFVHDCCYEKVTGCDPKWSYYTYSLENGDIVCEGDPYCTKVKCECDKKAAIC | ||||||
Disulfide bond | 49↔122 | |||||
Sequence: CCYEKVTGCDPKWSYYTYSLENGDIVCEGDPYCTKVKCECDKKAAICFRDNLKTYKNRYMTFPDIFCTDPTEGC | ||||||
Disulfide bond | 50↔88 | |||||
Sequence: CYEKVTGCDPKWSYYTYSLENGDIVCEGDPYCTKVKCEC | ||||||
Disulfide bond | 57↔81 | |||||
Sequence: CDPKWSYYTYSLENGDIVCEGDPYC | ||||||
Disulfide bond | 75↔86 | |||||
Sequence: CEGDPYCTKVKC |
Keywords
- PTM
Expression
Tissue specificity
Expressed by the venom gland.