P59265 · PA2BB_PROFL

Function

function

Snake venom phospholipase A2 (PLA2) that displays edema-inducing activities. PLA-B is three times more active than PLA-A in edema-inducing activities. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion.

Features

Showing features for binding site, active site.

1122102030405060708090100110120
TypeIDPosition(s)Description
Binding site27Ca2+ (UniProtKB | ChEBI)
Binding site29Ca2+ (UniProtKB | ChEBI)
Binding site31Ca2+ (UniProtKB | ChEBI)
Active site47
Binding site48Ca2+ (UniProtKB | ChEBI)
Active site89

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functioncalcium ion binding
Molecular Functioncalcium-dependent phospholipase A2 activity
Molecular Functionphospholipid binding
Molecular Functiontoxin activity
Biological Processarachidonic acid secretion
Biological Processlipid catabolic process
Biological Processphospholipid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Basic phospholipase A2 PLA-B
  • EC number
  • Short names
    svPLA2
  • Alternative names
    • Phosphatidylcholine 2-acylhydrolase

Organism names

Accessions

  • Primary accession
    P59265

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00001617001-122Basic phospholipase A2 PLA-B
Disulfide bond26↔115
Disulfide bond28↔44
Disulfide bond43↔95
Disulfide bond49↔122
Disulfide bond50↔88
Disulfide bond57↔81
Disulfide bond75↔86

Keywords

Expression

Tissue specificity

Expressed by the venom gland.

Structure

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    122
  • Mass (Da)
    14,053
  • Last updated
    1988-01-01 v1
  • Checksum
    7F0EB2276C5D0F52
HLLQFRKMIKKMTGKEPIVSYAFYGCYCGKGGRGKPKDATDRCCFVHDCCYEKVTGCDPKWSYYTYSLENGDIVCEGDPYCTKVKCECDKKAAICFRDNLKTYKNRYMTFPDIFCTDPTEGC

Keywords

Similar Proteins

Disclaimer

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