P59075 · GMPR_PHYIN

Function

function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity).

Catalytic activity

Features

Showing features for binding site, active site.

136250100150200250300350
TypeIDPosition(s)Description
Binding site26-27NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits
Binding site78NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site129-131NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site180-181NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site181K+ (UniProtKB | ChEBI)
Binding site183K+ (UniProtKB | ChEBI)
Active site186Thioimidate intermediate
Binding site186K+ (UniProtKB | ChEBI)
Active site188Proton donor/acceptor
Binding site189K+ (UniProtKB | ChEBI)
Binding site219-221GMP (UniProtKB | ChEBI)
Binding site242-243GMP (UniProtKB | ChEBI)
Binding site268-270GMP (UniProtKB | ChEBI)
Binding site269NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site285-286NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site286-290GMP (UniProtKB | ChEBI)
Binding site314-317NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentGMP reductase complex
Molecular FunctionGMP reductase activity
Molecular Functionmetal ion binding
Biological Processpurine nucleobase metabolic process
Biological Processpurine nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GMP reductase
  • EC number
  • Alternative names
    • Guanosine 5'-monophosphate oxidoreductase (Guanosine monophosphate reductase)

Organism names

Accessions

  • Primary accession
    P59075

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000937311-362GMP reductase

Structure

Family & Domains

Sequence similarities

Belongs to the IMPDH/GMPR family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    362
  • Mass (Da)
    38,924
  • Last updated
    2002-11-08 v1
  • Checksum
    C15F5F041372F5EC
MPRIETEVRLDFKDVLIRPKRSTLKSRSQVDVQREFRFLNSKRTWSGVPVIAANMDTVGTFEMAVELAKLEFITCVHKHYTPQDWATFAAKHPDVLPTVAVSGGSSAADVEKITAILKSHPDIRFICLDVANGYSEVFVQAVRNVRSAFPEHTIIAGNVVTGEMVEELLLSGADIIKVGIGPGSVCTTRKQTGVGYPQLSAVLECADAAHGLNGHVISDGGCTCPGDVAKAFGAGADFVMLGGMLAGHDESGGDKIEINGKLLKKFYGMSSSEAMKKHNGGVAEYRASEGKSVTVPYRGPVSGTCKEILGGVRSTCTYVGASKLKEISKRTTFIRVSQQLNEVFGRAPNEQEEQVSKKQKTG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF424648
EMBL· GenBank· DDBJ
AAN31473.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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