P59075 · GMPR_PHYIN
- ProteinGMP reductase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids362 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity).
Catalytic activity
- IMP + NADP+ + NH4+ = GMP + 2 H+ + NADPH
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 26-27 | NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits | ||||
Sequence: SR | ||||||
Binding site | 78 | NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain | ||||
Sequence: K | ||||||
Binding site | 129-131 | NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain | ||||
Sequence: DVA | ||||||
Binding site | 180-181 | NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain | ||||
Sequence: IG | ||||||
Binding site | 181 | K+ (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 183 | K+ (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Active site | 186 | Thioimidate intermediate | ||||
Sequence: C | ||||||
Binding site | 186 | K+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Active site | 188 | Proton donor/acceptor | ||||
Sequence: T | ||||||
Binding site | 189 | K+ (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 219-221 | GMP (UniProtKB | ChEBI) | ||||
Sequence: DGG | ||||||
Binding site | 242-243 | GMP (UniProtKB | ChEBI) | ||||
Sequence: GG | ||||||
Binding site | 268-270 | GMP (UniProtKB | ChEBI) | ||||
Sequence: GMS | ||||||
Binding site | 269 | NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain | ||||
Sequence: M | ||||||
Binding site | 285-286 | NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain | ||||
Sequence: YR | ||||||
Binding site | 286-290 | GMP (UniProtKB | ChEBI) | ||||
Sequence: RASEG | ||||||
Binding site | 314-317 | NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits | ||||
Sequence: STCT |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | GMP reductase complex | |
Molecular Function | GMP reductase activity | |
Molecular Function | metal ion binding | |
Biological Process | purine nucleobase metabolic process | |
Biological Process | purine nucleotide metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGMP reductase
- EC number
- Alternative names
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Stramenopiles > Oomycota > Peronosporales > Peronosporaceae > Phytophthora
Accessions
- Primary accessionP59075
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000093731 | 1-362 | GMP reductase | |||
Sequence: MPRIETEVRLDFKDVLIRPKRSTLKSRSQVDVQREFRFLNSKRTWSGVPVIAANMDTVGTFEMAVELAKLEFITCVHKHYTPQDWATFAAKHPDVLPTVAVSGGSSAADVEKITAILKSHPDIRFICLDVANGYSEVFVQAVRNVRSAFPEHTIIAGNVVTGEMVEELLLSGADIIKVGIGPGSVCTTRKQTGVGYPQLSAVLECADAAHGLNGHVISDGGCTCPGDVAKAFGAGADFVMLGGMLAGHDESGGDKIEINGKLLKKFYGMSSSEAMKKHNGGVAEYRASEGKSVTVPYRGPVSGTCKEILGGVRSTCTYVGASKLKEISKRTTFIRVSQQLNEVFGRAPNEQEEQVSKKQKTG |
Structure
Sequence
- Sequence statusComplete
- Length362
- Mass (Da)38,924
- Last updated2002-11-08 v1
- ChecksumC15F5F041372F5EC