P50449 · PAI1_NEOVI
- ProteinPlasminogen activator inhibitor 1
- GeneSERPINE1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids400 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence (By similarity).
Plays a role in alveolar type 2 cells senescence in the lung (By similarity).
Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).
Plays a role in alveolar type 2 cells senescence in the lung (By similarity).
Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 367-368 | Reactive bond | ||||
Sequence: RM |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Molecular Function | serine-type endopeptidase inhibitor activity | |
Biological Process | negative regulation of plasminogen activation | |
Biological Process | negative regulation of vascular wound healing | |
Biological Process | replicative senescence |
Keywords
- Molecular function
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended namePlasminogen activator inhibitor 1
- Short namesPAI; PAI-1
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Musteloidea > Mustelidae > Mustelinae > Neogale
Accessions
- Primary accessionP50449
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MQMSTVCLALGLALVFGEASA | ||||||
Chain | PRO_0000032501 | 22-400 | Plasminogen activator inhibitor 1 | |||
Sequence: SYLHETRAAELATDFGVKVFKQVAQASKDRNMVFSPYGLASVLAMLQLTTAGETRQQIQEAMRFQIDEKGMAPALRQLYKELMGPWNKDEISTADAIFVQRDLKLVHGFMPYFFRLFQTTVKQVDFSEVERARFIINDWVKRHTKGMIGDLLGRGTVDQLTRLMLVNALYFNGQWKTPFPKSGTHHRLFHKSDGSTVSVPMMAQTNKFNYTEFSTPEGRYYDILELPYHGDTLSMFIAAPYEKDVPLSALTNILDAQLISQWKGNMTRRLRLLVLPKFSLESEVNLRGPLENLGMTDMFRPNQADFSSLSDQEALYVSQALQKVKIEVNESGTVASSSTAIIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP | ||||||
Glycosylation | 230 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 286 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 350 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Interaction
Subunit
Forms a heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Interacts with PPP1CB. In complex with PLAU/uPA, interacts with PLAUR/uPAR (By similarity).
Interacts with SORL1 and LRP1, either alone or in complex with PLAU; these interactions are abolished in the presence of LRPAP1/RAP (By similarity).
The ternary complex composed of PLAUR-PLAU-PAI1 also interacts with SORL1 (By similarity).
Also interacts with SORL1, when complexed to PLAT/tPA (By similarity).
Interacts with SORL1 and LRP1, either alone or in complex with PLAU; these interactions are abolished in the presence of LRPAP1/RAP (By similarity).
The ternary complex composed of PLAUR-PLAU-PAI1 also interacts with SORL1 (By similarity).
Also interacts with SORL1, when complexed to PLAT/tPA (By similarity).
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length400
- Mass (Da)45,153
- Last updated1996-10-01 v1
- ChecksumDF45E0694DE28401
Keywords
- Technical term