P50215 · IDH_SPHYA

Function

function

Catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate and carbon dioxide with the concomitant reduction of NADP+.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mg2+ or Mn2+ ion per subunit.

Features

Showing features for binding site, site.

140650100150200250300350400
TypeIDPosition(s)Description
Binding site72NADP+ (UniProtKB | ChEBI)
Binding site75NADP+ (UniProtKB | ChEBI)
Binding site77NADP+ (UniProtKB | ChEBI)
Binding site82NADP+ (UniProtKB | ChEBI)
Binding site94D-threo-isocitrate (UniProtKB | ChEBI)
Binding site96D-threo-isocitrate (UniProtKB | ChEBI)
Binding site100D-threo-isocitrate (UniProtKB | ChEBI)
Binding site110D-threo-isocitrate (UniProtKB | ChEBI)
Binding site132D-threo-isocitrate (UniProtKB | ChEBI)
Site139Critical for catalysis
Site210Critical for catalysis
Binding site250Mn2+ (UniProtKB | ChEBI)
Binding site273Mn2+ (UniProtKB | ChEBI)
Binding site277Mn2+ (UniProtKB | ChEBI)
Binding site308NADP+ (UniProtKB | ChEBI)
Binding site309NADP+ (UniProtKB | ChEBI)
Binding site310NADP+ (UniProtKB | ChEBI)
Binding site313NADP+ (UniProtKB | ChEBI)
Binding site326NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionisocitrate dehydrogenase (NADP+) activity
Molecular Functionmagnesium ion binding
Molecular FunctionNAD binding
Biological Processglyoxylate cycle
Biological Processisocitrate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Isocitrate dehydrogenase [NADP]
  • EC number
  • Short names
    IDH
  • Alternative names
    • IDP
    • NADP(+)-specific ICDH
    • Oxalosuccinate decarboxylase

Gene names

    • Name
      icd
    • Synonyms
      idhA

Organism names

Accessions

  • Primary accession
    P50215

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000835671-406Isocitrate dehydrogenase [NADP]

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    406
  • Mass (Da)
    45,483
  • Last updated
    1996-10-01 v1
  • Checksum
    093F7E18303A89E7
MAKIKVKNPVVEIDGDEMTRIIWEWIRERLILPYLDVDLKYYDLSVEKRDETSDQITIDAANAIKEYGVGVKCATITPDEARVEEFGLKKMWKSPNGTIRNILGGVVFREPIVIKNVPRLVPGWTDPIVVGRHAFGDQYKATDFKVPGAGTLTMKWVGTNGEELEYEVFEFPSAGVAMGMYNLDESIRDFAKASFNYGLNRGWPVYLSTKNTILKAYDGRFKDLFQEVFDAEFADKFKAAGIVYEHRLIDDMVASALKWSGKFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLLSPDGKTVEAEAAHGTVTRHYRQHQQGKATSTNPIASIFAWTQGLSFRGKFDDTPDVVKFAETLEQVCIKTVEGGAMTKDLALLIGPDQAWMTTEQFFEAIRVNLEAEMAKWA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U37523
EMBL· GenBank· DDBJ
AAC43640.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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