P47959 · HPRT_MERUN

Function

function

Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein.

Pathway

Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site69GMP (UniProtKB | ChEBI)
Binding site134-142GMP (UniProtKB | ChEBI)
Active site138Proton acceptor
Binding site166GMP (UniProtKB | ChEBI)
Binding site186-188GMP (UniProtKB | ChEBI)
Binding site194GMP (UniProtKB | ChEBI)
Binding site194Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Molecular Functionguanine phosphoribosyltransferase activity
Molecular Functionhypoxanthine phosphoribosyltransferase activity
Molecular Functionidentical protein binding
Molecular Functionmagnesium ion binding
Molecular Functionnucleotide binding
Biological ProcessGMP catabolic process
Biological ProcessGMP salvage
Biological Processguanine salvage
Biological Processhypoxanthine metabolic process
Biological Processhypoxanthine salvage
Biological ProcessIMP metabolic process
Biological ProcessIMP salvage
Biological Processpositive regulation of dopamine metabolic process
Biological Processpurine nucleotide biosynthetic process
Biological Processpurine ribonucleoside salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hypoxanthine-guanine phosphoribosyltransferase
  • EC number
  • Short names
    HGPRT; HGPRTase

Gene names

    • Name
      HPRT1
    • Synonyms
      HPRT

Organism names

Accessions

  • Primary accession
    P47959

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain, cross-link.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylalanine
ChainPRO_00001395872-218Hypoxanthine-guanine phosphoribosyltransferase
Modified residue103N6-acetyllysine
Cross-link115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate
Cross-link115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate
Modified residue142Phosphothreonine

Keywords

Interaction

Subunit

Homotetramer.

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    218
  • Mass (Da)
    24,538
  • Last updated
    2007-01-23 v2
  • Checksum
    589C500AD78CE9FC
MATRSPSIVIGDDEPGYDLDLFCIPKHYAEDLEKVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKSLNRNTDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSALTGKNVLIVEDIIDTGKTMQTLLSLVQKYSPKMVKVASLLVKRTPRSVGYRPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISESGKAKYKA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L37778
EMBL· GenBank· DDBJ
AAA65676.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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