P47790 · MYPR_TAEGU

Function

function

This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmyelin sheath
Cellular Componentplasma membrane
Molecular Functionstructural constituent of myelin sheath
Biological Processaxon development
Biological Processcentral nervous system myelination

Names & Taxonomy

Protein names

  • Recommended name
    Myelin proteolipid protein
  • Short names
    PLP
  • Alternative names
    • Lipophilin

Gene names

    • Name
      PLP1
    • Synonyms
      PLP

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia

Accessions

  • Primary accession
    P47790

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain2-10Cytoplasmic
Transmembrane11-36Helical; Name=1
Topological domain37-59Extracellular
Transmembrane60-88Helical; Name=2
Topological domain89-151Cytoplasmic
Transmembrane152-178Helical; Name=3
Topological domain179-238Extracellular
Transmembrane239-268Helical; Name=4
Topological domain269-277Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for initiator methionine, chain, lipidation, disulfide bond.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00001590112-277Myelin proteolipid protein
Lipidation6S-palmitoyl cysteine
Lipidation7S-palmitoyl cysteine
Lipidation10S-palmitoyl cysteine
Lipidation109S-palmitoyl cysteine
Lipidation139S-palmitoyl cysteine
Lipidation141S-palmitoyl cysteine
Disulfide bond184↔228
Lipidation199O-palmitoyl threonine
Disulfide bond201↔220

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the myelin proteolipid protein family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    277
  • Mass (Da)
    30,228
  • Last updated
    2007-01-23 v2
  • Checksum
    95E9DCEF25C20D6A
MGLLECCARCLIGAPFASLVATGLCFFGVALFCGCGHEALTGTEQLIETYFSKNYQDYEFLIDVIHGFQYFIYGTAAFFFLYGALLLAEGFYTTGAVRQIFGDYRTTICGKGLSATVTGGPKGRGARGPQRAHSWQRVCHCLGKWLGHPDKFVGITYVLTIIWLLVFACSAVPVYIYFNTWTTCQSIGNPTKTSASIGTLCADARMYGILPWNAFPGKVCGSNLLSICKTSEFQMTFHLFIAAFVGAAATLVSLVTFIIATTYNFAVLRLMGRGTKF

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H0Z825H0Z825_TAEGUPLP1256
A0A674GW55A0A674GW55_TAEGUPLP1277

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
S75729
EMBL· GenBank· DDBJ
AAB32825.2
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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