P41745 · EF1A_BLAAD
- ProteinElongation factor 1-alpha
- GeneTEF
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids459 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | translation elongation factor activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameElongation factor 1-alpha
- Short namesEF-1-alpha
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Trichomonascaceae > Blastobotrys
Accessions
- Primary accessionP41745
Subcellular Location
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N,N,N-trimethylglycine | ||||
Sequence: G | ||||||
Chain | PRO_0000090951 | 2-459 | Elongation factor 1-alpha | |||
Sequence: GKEKTHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERVITIDIALWKFETPKYYVTVIDAPGHRDFIKNMITGTSQADCAILIIAGGTGEFEAGISKDGQTREHALLAFTLGVRQLIVAINKMDSVNWSEDRYNEIVKETSNFIKKVGFNPKAVPFVPISGWNGDNMIEATTNASWYKGWHKETKEGKATGKTLLEAIDAVDPPTRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKPGMVVTFAPAGVTTEVKSVEMHHEQLPEGLPGDNVGFNVKNVSVKEIRRGNVAGDSKNDPPKGCDSFTAQVIIFNHPGQISAGYSPVLDCHTAHIACRFDELIEKIDRRSGKKVEDSPKFVKAGDAAIVRMIPSKPMCVETFTEYPPLGRFAVRDMRQTVAVGVIKSVEKSDKGAGKVTKAAQKAAKK | ||||||
Modified residue | 3 | N6,N6-dimethyllysine; alternate | ||||
Sequence: K | ||||||
Modified residue | 3 | N6-methyllysine; alternate | ||||
Sequence: K | ||||||
Modified residue | 30 | N6-methyllysine | ||||
Sequence: K | ||||||
Modified residue | 79 | N6,N6,N6-trimethyllysine | ||||
Sequence: K | ||||||
Modified residue | 316 | N6,N6-dimethyllysine; alternate | ||||
Sequence: K | ||||||
Modified residue | 316 | N6-methyllysine; alternate | ||||
Sequence: K | ||||||
Modified residue | 390 | N6-methyllysine | ||||
Sequence: K |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-240 | tr-type G | ||||
Sequence: KTHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERVITIDIALWKFETPKYYVTVIDAPGHRDFIKNMITGTSQADCAILIIAGGTGEFEAGISKDGQTREHALLAFTLGVRQLIVAINKMDSVNWSEDRYNEIVKETSNFIKKVGFNPKAVPFVPISGWNGDNMIEATTNASWYKGWHKETKEGKATGKTLLEAIDAVDPPTRPS | ||||||
Region | 14-21 | G1 | ||||
Sequence: GHVDSGKS | ||||||
Region | 70-74 | G2 | ||||
Sequence: VITID | ||||||
Region | 91-94 | G3 | ||||
Sequence: DAPG | ||||||
Region | 153-156 | G4 | ||||
Sequence: NKMD | ||||||
Region | 192-194 | G5 | ||||
Sequence: SGW |
Sequence similarities
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length459
- Mass (Da)50,116
- Last updated1995-11-01 v1
- Checksum2E7A08107D0BF3F6