P38594 · CYB_LEPWE
- ProteinCytochrome b
- GeneMT-CYB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids379 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Miscellaneous
Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
Cofactor
Note: Binds 2 heme b groups non-covalently.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 83 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 97 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 182 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 196 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 201 | a ubiquinone (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex III | |
Molecular Function | metal ion binding | |
Molecular Function | ubiquinol-cytochrome-c reductase activity | |
Biological Process | mitochondrial electron transport, ubiquinol to cytochrome c |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome b
- Alternative names
Gene names
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Pinnipedia > Phocidae > Leptonychotes
Accessions
- Primary accessionP38594
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 33-53 | Helical | ||||
Sequence: FGSLLGICLILQILTGLFLAM | ||||||
Transmembrane | 77-98 | Helical | ||||
Sequence: WIIRYMHANGASMFFICLYMHV | ||||||
Transmembrane | 113-133 | Helical | ||||
Sequence: WNIGIILLFTVMATAFMGYVL | ||||||
Transmembrane | 178-198 | Helical | ||||
Sequence: FFAFHFILPFVVSALAAVHLL | ||||||
Transmembrane | 226-246 | Helical | ||||
Sequence: IKDILGALLLILTLMLLVLFS | ||||||
Transmembrane | 288-308 | Helical | ||||
Sequence: LGGVLALALSILILAIIPLLH | ||||||
Transmembrane | 320-340 | Helical | ||||
Sequence: ISQCLFWLLVADLLTLTWIGG | ||||||
Transmembrane | 347-367 | Helical | ||||
Sequence: YITIGQLASILYFTILLVLMP |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000061116 | 1-379 | Cytochrome b | |||
Sequence: MTNIRKTHPLAKIINNSFIDLPTPSNISAWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLYMHVGRGLYYGSYTFTETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGFSVDKATLTRFFAFHFILPFVVSALAAVHLLFLHETGSNNPSGIPSDSDKIPFHPYYTIKDILGALLLILTLMLLVLFSPDLLGDPDNYTPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALALSILILAIIPLLHTSKQRGMMFRPISQCLFWLLVADLLTLTWIGGQPVEHPYITIGQLASILYFTILLVLMPITSIIENNILKW |
Interaction
Subunit
The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
Structure
Sequence
- Sequence statusComplete
- Length379
- Mass (Da)42,545
- Last updated1994-10-01 v1
- Checksum1B17CC1C2D2714B7
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X72005 EMBL· GenBank· DDBJ | CAA50890.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM181025 EMBL· GenBank· DDBJ | CAJ57000.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U12843 EMBL· GenBank· DDBJ | AAA67253.1 EMBL· GenBank· DDBJ | Genomic DNA |