P33974 · TRPG_HALVD

Function

function

Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).

Catalytic activity

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site58-60L-glutamine (UniProtKB | ChEBI)
Active site88Nucleophile; for GATase activity
Binding site138-139L-glutamine (UniProtKB | ChEBI)
Active site178For GATase activity
Active site180For GATase activity

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionanthranilate synthase activity
Biological Processglutamine metabolic process
Biological Processtryptophan biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Anthranilate synthase component 2
  • EC number
  • Short names
    AS; ASII
  • Alternative names
    • Anthranilate synthase, GATase component
    • Anthranilate synthase, glutamine amidotransferase component

Gene names

    • Name
      trpG
    • Ordered locus names
      HVO_2453

Organism names

Accessions

  • Primary accession
    P33974
  • Secondary accessions
    • D4GT35

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000568831-204Anthranilate synthase component 2

Proteomic databases

Interaction

Subunit

Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-204Glutamine amidotransferase type-1

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    204
  • Mass (Da)
    21,849
  • Last updated
    2011-09-21 v2
  • Checksum
    6FC8FCE64599C444
MIRLVVVDNFDSFTYNLVEYFSEQTVEGEPLDIEVRKNTASLDEIRDLDPDAIVISPGPGHPKNDRDVGVTNDVLTELSTEIPTLGVCLGLEAAVYAYGGTIGHAPEPIHGKAFPVDHDGAGVFAGLEDGFPAGRYHSLVATDVPDCFDVSATTDHDGEALVMGVRHRDYPIECVQFHPESVLTGSGHGVVRNFLTAVAGFDVA

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict38in Ref. 1; AAA73178
Sequence conflict107-108in Ref. 1; AAA73178

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M83788
EMBL· GenBank· DDBJ
AAA73178.1
EMBL· GenBank· DDBJ
Genomic DNA
CP001956
EMBL· GenBank· DDBJ
ADE03081.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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