P24979 · NU5M_CYPCA

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial respiratory chain complex I
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular FunctionNADH dehydrogenase activity
Biological ProcessATP synthesis coupled electron transport
Biological Processelectron transport coupled proton transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 5
  • EC number
  • Alternative names
    • NADH dehydrogenase subunit 5

Gene names

    • Name
      MT-ND5
    • Synonyms
      MTND5, NADH5, ND5

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Cyprinidae > Cyprininae > Cyprinus

Accessions

  • Primary accession
    P24979

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane1-21Helical
Transmembrane44-64Helical
Transmembrane88-108Helical
Transmembrane118-138Helical
Transmembrane139-159Helical
Transmembrane172-192Helical
Transmembrane213-235Helical
Transmembrane243-263Helical
Transmembrane274-294Helical
Transmembrane303-323Helical
Transmembrane326-346Helical
Transmembrane372-392Helical
Transmembrane415-435Helical
Transmembrane450-470Helical
Transmembrane484-504Helical
Transmembrane587-607Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001180851-607NADH-ubiquinone oxidoreductase chain 5

Structure

Family & Domains

Sequence similarities

Belongs to the complex I subunit 5 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    607
  • Mass (Da)
    67,368
  • Last updated
    1992-03-01 v1
  • Checksum
    DEFC96BEFD956BC5
MTLIMHSSLLLIFFILVYPLLTTLNPNQQDSNMAGMTKTAVSSAFFVSLLPLMIFLNLKTEGIITNWQWMNTQAFDVNISFKFDHYSLIFVPIALYVTWSILEFALWYMHSDPNIDRFFKYLLTFLVAMIILVTANNMFQLFIGWEGVGIMSFLLIGWWHGRADANTAALQAVIYNRVGDIGLIMTMAWLAMNLNSWEIQQIFALSKNFDMTIPLMGLALAATGKSAQFGLHPWLPVAMEGPTPVSALLHSSTMVVAGIFLLIRLHPRMENNQLALTTCLCLGALTSLFTATCALTQNDIKKIVAFSTSSQLGLMMVTIGLNQPQLAFLHICTHAFFKAMLFLCSGSIIHSLNDEQDIRKMGGLFNIMPATSTYFTIGSLALTGTPFLAGFFSKDAIIEALNTSYLNAWALTLTLIATSFTAVYSFRLVYFVIMGTPRFLPLSPINENNPLVINTIKRLAWGSIIAGLIITQNFPPMKTPIMTMSITLKMAALMVTIAGLLVAMELANLTSKQVKITPMISTHHFSNMLGFYPMIIHRLIPKLKLTLGQSAATQLDKTWLETVGPKGLALTQMAMAKITNDITRGMIKTYLTIFLLTLILATIPVLL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X61010
EMBL· GenBank· DDBJ
CAA43337.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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