P24618 · GRM_MICEC

Function

function

Specifically methylates the N7 position of guanine 1405 in 16S rRNA. Confers resistance to various aminoglycosides, including gentamicin and kanamycin.

Miscellaneous

Protects M.echinospora, which is an antibiotic-producing bacterium, against self-intoxication.

Catalytic activity

Features

Showing features for binding site.

127420406080100120140160180200220240260
TypeIDPosition(s)Description
Binding site64S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site102-104S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site108S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site133S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site156S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site182-183S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site198S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site207S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionrRNA methyltransferase activity
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    16S rRNA (guanine(1405)-N(7))-methyltransferase
  • EC number
  • Alternative names
    • 16S rRNA m7G1405 methyltransferase
    • Gentamicin-resistance methyltransferase

Gene names

    • Name
      grm
    • Synonyms
      grmA

Organism names

Accessions

  • Primary accession
    P24618

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000838541-27416S rRNA (guanine1405-N7)-methyltransferase

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    274
  • Mass (Da)
    30,542
  • Last updated
    1992-03-01 v1
  • Checksum
    9D7289559621A68E
MTTSAPEDRIDQVEQAITKSRRYQTVAPATVRRLARAALVAARGDVPDAVKRTKRGLHEIYGAFLPPSPPNYAALLRQLDSAVDAGDDEAVRAALRRAMSVHVSTRERLPHLAEFYQEIFRHVPQPNTLRDLACGLNPLAAPWMGLSDQTVYVASDIDARLIGFVDAALTRLGVAHRTSVVDLLEDRLDEPTDVTLLLKTLPCLETQRRGSGWEVIDIVNSPIIVVTFPTKSLGQRSKGMFQNYSQSFESQARERSCRIQRLEIGNELIYVIQK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M55520
EMBL· GenBank· DDBJ
AAA25336.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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