P21977 · GALE_STRTR

Function

function

Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD.

Catalytic activity

Cofactor

NAD+ (UniProtKB | Rhea| CHEBI:57540 )

Pathway

Carbohydrate metabolism; galactose metabolism.

Features

Showing features for binding site, active site.

133250100150200250300
TypeIDPosition(s)Description
Binding site11-12NAD+ (UniProtKB | ChEBI)
Binding site32-37NAD+ (UniProtKB | ChEBI)
Binding site52-53NAD+ (UniProtKB | ChEBI)
Binding site75-79NAD+ (UniProtKB | ChEBI)
Binding site94NAD+ (UniProtKB | ChEBI)
Binding site119NAD+ (UniProtKB | ChEBI)
Binding site119substrate
Active site143Proton acceptor
Binding site143NAD+ (UniProtKB | ChEBI)
Binding site143substrate
Binding site147NAD+ (UniProtKB | ChEBI)
Binding site171NAD+ (UniProtKB | ChEBI)
Binding site172substrate
Binding site190-191substrate
Binding site207-209substrate
Binding site222substrate
Binding site283-286substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionUDP-glucose 4-epimerase activity
Biological Processgalactose catabolic process via UDP-galactose

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-glucose 4-epimerase
  • EC number
  • Alternative names
    • Galactowaldenase
    • UDP-galactose 4-epimerase

Gene names

    • Name
      galE

Organism names

Accessions

  • Primary accession
    P21977

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001832211-332UDP-glucose 4-epimerase

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    332
  • Mass (Da)
    36,940
  • Last updated
    1991-08-01 v1
  • Checksum
    642D84CF72E2532E
MAILVLGGAGYIGSHMVDRLVEKGQEKVVVVDSLVTGHRAAVHPDAIFYQGDLSDQDFMRKVFKENPDVDAVIHFAAYSLVGESMEKPLKYFDNNTAGMVKLLEVMNECGVKYIVFSSTAATYGIPEEIPILETTPQNPINPYGESKLMMETIMKWSDQAYGIKYVPLRYFNVAGANLMVRLVRTRSETHLLPIILQVAQGVREKIMIFGDDYNTPDGTNVRDYVHPFDLADAHLLAVEYLRKGNESTAFNLGSSTGFSNLQILEAARKVTGKEIPAEKADRRPGDPDILIASSEKARTVLGWKPQFDNIEKIIASAWAWHSSHPKGYDDRG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M38175
EMBL· GenBank· DDBJ
AAA26944.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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