P21977 · GALE_STRTR
- ProteinUDP-glucose 4-epimerase
- GenegalE
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids332 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD.
Catalytic activity
- UDP-alpha-D-glucose = UDP-alpha-D-galactose
Cofactor
Pathway
Carbohydrate metabolism; galactose metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 11-12 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: YI | ||||||
Binding site | 32-37 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: DSLVTG | ||||||
Binding site | 52-53 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: DL | ||||||
Binding site | 75-79 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: FAAYS | ||||||
Binding site | 94 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 119 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 119 | substrate | ||||
Sequence: T | ||||||
Active site | 143 | Proton acceptor | ||||
Sequence: Y | ||||||
Binding site | 143 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 143 | substrate | ||||
Sequence: Y | ||||||
Binding site | 147 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 171 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 172 | substrate | ||||
Sequence: N | ||||||
Binding site | 190-191 | substrate | ||||
Sequence: HL | ||||||
Binding site | 207-209 | substrate | ||||
Sequence: MIF | ||||||
Binding site | 222 | substrate | ||||
Sequence: R | ||||||
Binding site | 283-286 | substrate | ||||
Sequence: RPGD |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | UDP-glucose 4-epimerase activity | |
Biological Process | galactose catabolic process via UDP-galactose |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUDP-glucose 4-epimerase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionP21977
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000183221 | 1-332 | UDP-glucose 4-epimerase | |||
Sequence: MAILVLGGAGYIGSHMVDRLVEKGQEKVVVVDSLVTGHRAAVHPDAIFYQGDLSDQDFMRKVFKENPDVDAVIHFAAYSLVGESMEKPLKYFDNNTAGMVKLLEVMNECGVKYIVFSSTAATYGIPEEIPILETTPQNPINPYGESKLMMETIMKWSDQAYGIKYVPLRYFNVAGANLMVRLVRTRSETHLLPIILQVAQGVREKIMIFGDDYNTPDGTNVRDYVHPFDLADAHLLAVEYLRKGNESTAFNLGSSTGFSNLQILEAARKVTGKEIPAEKADRRPGDPDILIASSEKARTVLGWKPQFDNIEKIIASAWAWHSSHPKGYDDRG |
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length332
- Mass (Da)36,940
- Last updated1991-08-01 v1
- Checksum642D84CF72E2532E