P21921 · COBL_SINSX

  • Protein
    Precorrin-6Y C(5,15)-methyltransferase [decarboxylating]
  • Gene
    cobL
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Catalyzes the methylation of both C-5 and C-15 in precorrin-6Y to form precorrin-8X.

Caution

Was originally thought to originate from Pseudomonas denitrificans, but similarity searches show that the sequence is much closer to Sinorhizobium. The entry's taxonomy has been changed.

Catalytic activity

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 7/10.

GO annotations

AspectTerm
Molecular Functionprecorrin-6Y C5,15-methyltransferase (decarboxylating) activity
Molecular Functionprotein methyltransferase activity
Biological Processcobalamin biosynthetic process
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Precorrin-6Y C(5,15)-methyltransferase [decarboxylating]
  • EC number
  • Short names
    Precorrin-6 methyltransferase; Precorrin-6Y methylase

Gene names

    • Name
      cobL

Organism names

  • Taxonomic identifier
  • Strain
    • SC510
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Rhizobiaceae > Sinorhizobium/Ensifer group > Sinorhizobium

Accessions

  • Primary accession
    P21921

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001504081-413Precorrin-6Y C(5,15)-methyltransferase [decarboxylating]

Structure

Family & Domains

Sequence similarities

Belongs to the precorrin methyltransferase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    413
  • Mass (Da)
    42,938
  • Last updated
    1991-05-01 v1
  • Checksum
    C78E174A79F94249
MADVSNSEPAIVSPWLTVIGIGEDGVAGLGDEAKRLIAEAPVVYGGHRHLELAASLITGEAHNWLSPLERSVVEIVARRGSPVVVLASGDPFFFGVGVTLARRIASAEIRTLPAPSSISLAASRLGWALQDATLVSVHGRPLDLVRPHLHPGARVLTLTSDGAGPRDLAELLVSSGFGQSRLTVLEALGGAGERVTTQIAARFMLGLVHPLNVCAIEVAADEGARILPLAAGRDDALFEHDGQITKREVRALTLSALAPRKGELLWDIGGGSGSIGIEWMLADPTMQAITIEVEPERAARIGRNATMFGVPGLTVVEGEAPAALAGLPQPDAIFIGGGGSEDGVMEAAIEALKSGGRLVANAVTTDMEAVLLDHHARLGGSLIRIDIARAGPIGGMTGWKPAMPVTQWSWTKG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M59301
EMBL· GenBank· DDBJ
AAA25800.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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