P21637 · COBG_SINSX
- ProteinPrecorrin-3B synthase
- GenecobG
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids459 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the elimination of C-20 in precorrin-3A to form precorrin-3B.
Catalytic activity
- 2 H+ + NADH + O2 + precorrin-3A = H2O + NAD+ + precorrin-3B
Pathway
Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 2/10.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 338 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 344 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 377 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 381 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 381 | Fe (UniProtKB | ChEBI) of siroheme (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Molecular Function | precorrin-3B synthase activity | |
Biological Process | cobalamin biosynthetic process | |
Biological Process | porphyrin-containing compound biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePrecorrin-3B synthase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Rhizobiaceae > Sinorhizobium/Ensifer group > Sinorhizobium
Accessions
- Primary accessionP21637
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000199966 | 1-459 | Precorrin-3B synthase | |||
Sequence: MTDLMTSCALPLTGDAGTVASMRRGACPSLAEPMQTGDGLLVRVRPTDDSLTLPKVIALATAAERFGNGIIEITARGNLQLRGLSAASVPRLAQAIGDAEIAIAEGLAIEVPPLAGIDPDEIADPRPIATELREALDVRQVPLKLAPKLSVVIDSGGRFGLGAVVADIRLQAVSTVAGVAWVLSLGGTSTKASSVGTLAGNAVVPALITILEKLASLGTTMRGRDLDPSEIRALCRCETSSERPAAPRSAAIPGIHALGNADTVLGLGLAFAQVEAAALASYLHQVQALGANAIRLAPGHAFFVLGLCPETAAVAQSLAASHGFRIAEQDPRNAIATCAGSKGCASAWMETKGMAERLVETAPELLDGSLTVHLSGCAKGCARPKPSELTLVGAPSGYGLVVNGAANGLPSAYTDENGMGSALARLGRLVRQNKDAGESAQSCLTRLGAARVSAAFEQG |
Structure
Sequence
- Sequence statusComplete
- Length459
- Mass (Da)46,691
- Last updated1996-02-01 v2
- ChecksumEC101F4C1FDC7209