P21352 · A1AG8_MUSCR

Function

function

Functions as a transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity).
Appears to function in modulating the activity of the immune system during the acute-phase reaction

Miscellaneous

Eight genes coding for different forms of alpha-1-AGP are present in mus carolis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Biological Processacute-phase response
Biological Processregulation of immune system process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-1-acid glycoprotein 8
  • Short names
    AGP 8
  • Alternative names
    • Orosomucoid-8 (OMD 8)

Gene names

    • Name
      Orm8
    • Synonyms
      Agp-8, Orm-8

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P21352

Proteomes

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant10
Natural variant24
Natural variant50
Natural variant98

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 4 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_000001786619-207Alpha-1-acid glycoprotein 8
Glycosylation25N-linked (GlcNAc...) asparagine
Glycosylation34N-linked (GlcNAc...) asparagine
Glycosylation76N-linked (GlcNAc...) asparagine
Disulfide bond91↔184
Glycosylation94N-linked (GlcNAc...) asparagine
Glycosylation104N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Expression

Tissue specificity

Expressed by the liver and secreted in plasma.

Structure

Family & Domains

Domain

Contains a beta-barrel that binds various ligands in its interior.

Sequence similarities

Belongs to the calycin superfamily. Lipocalin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    207
  • Mass (Da)
    23,912
  • Last updated
    1991-05-01 v1
  • Checksum
    2BADBF5EF94E7EB7
MALHTVLIMLSLLPMLEAQNPEHANITIGEPITNETLGWLSDKWFFMGAAFRKLEYRQAIQMMQTEFFYLTTNLINDTIELRESQTIGDQCVYNSTHLGFQRENGTFSKYEGGVETFAHLIVLRKHGAFMLAFDLNDEKKRGLSLYAKRPDMTLELREVFQKAVKHVGMDESEIIFVDWKKDKCGQQEKKQLELGKETKKDPEEGQA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M34649
EMBL· GenBank· DDBJ
AAA37198.1
EMBL· GenBank· DDBJ
mRNA
M34646
EMBL· GenBank· DDBJ
AAB67844.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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