P19713 · MCH1_ONCKE

Function

function

Plays a role in skin pigmentation by antagonizing the action of melanotropin alpha. Induces melanin concentration within the melanophores. May participate in the control of the hypothalamo-pituitary adrenal gland axis by inhibiting the release of ACTH.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentsynapse
Molecular Functionmelanin-concentrating hormone activity
Molecular Functiontype 1 melanin-concentrating hormone receptor binding
Biological Processchemical synaptic transmission
Biological Processneuropeptide signaling pathway

Keywords

Names & Taxonomy

Protein names

Gene names

    • Name
      mch1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Protacanthopterygii > Salmoniformes > Salmonidae > Salmoninae > Oncorhynchus

Accessions

  • Primary accession
    P19713
  • Secondary accessions
    • P01208

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain, peptide, disulfide bond.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_000001912025-132Pro-MCH 1
PeptidePRO_0000019121101-113Neuropeptide-glutamic acid-valine
PeptidePRO_0000019122116-132Melanin-concentrating hormone
Disulfide bond120↔129

Keywords

Expression

Tissue specificity

Pituitary gland. Produced in neurons of lateral basal hypothalamus which project both to the brain and to the neural lobe of the pituitary gland from where MCH is released.

Family & Domains

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    132
  • Mass (Da)
    14,682
  • Last updated
    1991-02-01 v1
  • Checksum
    CE9CF95292498738
MRHYVLSISFAVALFLECYTPSTAISIGKMDDVALEQDTLDSLLSVEVSENSPDSVRGRSSKIVLLADSGLWMNLNRGLPFYKLRAAAAGPDRALTLDRREAGQDLSPSISIVRRDTMRCMVGRVYRPCWEV

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict4in Ref. 2; AAA49420

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M27872
EMBL· GenBank· DDBJ
AAA49418.1
EMBL· GenBank· DDBJ
Genomic DNA
M23573
EMBL· GenBank· DDBJ
AAA49420.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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