P17980 · PRS6A_HUMAN

  • Protein
    26S proteasome regulatory subunit 6A
  • Gene
    PSMC3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Features

Showing features for binding site.

143950100150200250300350400
TypeIDPosition(s)Description
Binding site227-234ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentextracellular region
Cellular Componentficolin-1-rich granule lumen
Cellular Componentmembrane
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular ComponentP-body
Cellular Componentproteasome accessory complex
Cellular Componentproteasome complex
Cellular Componentproteasome regulatory particle, base subcomplex
Cellular Componentsecretory granule lumen
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionidentical protein binding
Molecular Functionproteasome-activating activity
Biological Processmodulation by host of viral transcription
Biological Processpositive regulation of proteasomal protein catabolic process
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processproteasome-mediated ubiquitin-dependent protein catabolic process

Keywords

Enzyme and pathway databases

Community curation (1)

The subsequence YLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTE, which contains the Prot_ATP_ID_OB domain, shows transcriptional repressor activity in a high-throughput recruitment assay.

Names & Taxonomy

Protein names

  • Recommended name
    26S proteasome regulatory subunit 6A
  • Alternative names
    • 26S proteasome AAA-ATPase subunit RPT5
    • Proteasome 26S subunit ATPase 3
    • Proteasome subunit P50
    • Tat-binding protein 1 (TBP-1)

Gene names

    • Name
      PSMC3
    • Synonyms
      TBP1
Community curation (1)

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P17980
  • Secondary accessions
    • B2R8V1
    • Q3B757
    • Q3B865
    • Q53HU5
    • Q6GPG8

Proteomes

Organism-specific databases

Disease & Variants

Involvement in disease

Deafness, cataract, impaired intellectual development, and polyneuropathy (DCIDP)

  • Note
    • The disease may be caused by variants affecting the gene represented in this entry
  • Description
    An autosomal recessive disease characterized by early onset of deafness, cataract, severe developmental delay, and severely impaired intellectual development. Patients later develop polyneuropathy of the lower extremities, associated with depigmentation of the hair in that area.
  • See also
    MIM:619354

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 334 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue, chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue1UniProtN-acetylmethionine
ChainPRO_00000846981-439UniProt26S proteasome regulatory subunit 6A
Modified residue9UniProtPhosphoserine
Modified residue (large scale data)9PRIDEPhosphoserine
Modified residue (large scale data)12PRIDEPhosphothreonine
Modified residue (large scale data)37PRIDEPhosphoserine
Modified residue376UniProtPhosphoserine
Modified residue (large scale data)376PRIDEPhosphoserine

Post-translational modification

Sumoylated by UBE2I in response to MEKK1-mediated stimuli.

Keywords

Proteomic databases

2D gel databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC3 and few additional components (PubMed:27342858, PubMed:27428775).
Interacts with PAAF1 (PubMed:15831487).
(Microbial infection) Interacts with HIV-1 Tat.

Binary interactions

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the AAA ATPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    439
  • Mass (Da)
    49,204
  • Last updated
    2002-05-10 v3
  • Checksum
    0E443465DDDEBB0B
MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA

Computationally mapped potential isoform sequences

There are 8 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
R4GNH3R4GNH3_HUMANPSMC3423
E9PS45E9PS45_HUMANPSMC337
E9PMW0E9PMW0_HUMANPSMC352
E9PLG2E9PLG2_HUMANPSMC3184
E9PM69E9PM69_HUMANPSMC3397
E9PMD8E9PMD8_HUMANPSMC3301
E9PN50E9PN50_HUMANPSMC3257
E9PKD5E9PKD5_HUMANPSMC3311

Sequence caution

The sequence AAI07805.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict356in Ref. 5; BAD96205
Sequence conflict409in Ref. 6; AAA36666

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK313518
EMBL· GenBank· DDBJ
BAG36298.1
EMBL· GenBank· DDBJ
mRNA
CH471064
EMBL· GenBank· DDBJ
EAW67916.1
EMBL· GenBank· DDBJ
Genomic DNA
BC008713
EMBL· GenBank· DDBJ
AAH08713.4
EMBL· GenBank· DDBJ
mRNA
BC073165
EMBL· GenBank· DDBJ
AAH73165.3
EMBL· GenBank· DDBJ
mRNA
BC106920
EMBL· GenBank· DDBJ
AAI06921.1
EMBL· GenBank· DDBJ
mRNA
BC107804
EMBL· GenBank· DDBJ
AAI07805.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK222485
EMBL· GenBank· DDBJ
BAD96205.1
EMBL· GenBank· DDBJ
mRNA
M34079
EMBL· GenBank· DDBJ
AAA36666.1
EMBL· GenBank· DDBJ
mRNA
CR456731
EMBL· GenBank· DDBJ
CAG33012.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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