P16153 · TCDE_CLODI

Function

function

Isoform 1

Holin-like protein required for secretion of toxins A and B (TcdA and TcdB) (PubMed:22685398).
Facilitates the release of toxins to the extracellular environment without causing the bacterial cell lysis (PubMed:22685398).

Isoform 2

Has weak activity, suggesting that it may act as a antiholin when multiple forms are produced.

Isoform 3

Has weak activity, suggesting that it may act as a antiholin when multiple forms are produced.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionpore-forming activity
Biological Processprotein transport

Keywords

Protein family/group databases

    • 1.E.19.3.1the clostridium difficile tcde holin (tcde holin) family

Names & Taxonomy

Protein names

  • Recommended name
    Holin-like protein TcdE

Gene names

    • Name
      tcdE
    • Synonyms
      utxA

Organism names

Accessions

  • Primary accession
    P16153

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane15-35Helical
Transmembrane36-56Helical
Transmembrane77-97Helical
Transmembrane111-131Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Cells grow normally but accumulate a strongly reduced amount of toxins TcdA and TcdB in the medium.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000226431-166Holin-like protein TcdE

Interaction

Subunit

Homomultimer.

Structure

Family & Domains

Sequence similarities

Belongs to the bacteriophage holin family.

Keywords

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative initiation.

P16153-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    Long
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    166
  • Mass (Da)
    18,800
  • Last updated
    1996-10-01 v2
  • Checksum
    1671FAE1884C7EE2
MHSSSPFYISNGNKIFFYINLGGVMNMTISFLSEHIFIKLVILTISFDTLLGCLSAIKSRKFNSSFGIDGGIRKVAMIACIFFLSVVDILTKFNFLFMLPQDCINFLRLKHLGISEFFSILFILYESVSILKNMCLCGLPVPKRLKEKIAILLDAMTDEMNAKDEK

P16153-2

  • Name
    2
  • Synonyms
    Short
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

P16153-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0607691-24in isoform 3
Alternative sequenceVSP_0188241-26in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X60984
EMBL· GenBank· DDBJ
CAA43300.1
EMBL· GenBank· DDBJ
Genomic DNA
X60984
EMBL· GenBank· DDBJ
CAA43301.1
EMBL· GenBank· DDBJ
Genomic DNA
M30308
EMBL· GenBank· DDBJ
AAA83532.1
EMBL· GenBank· DDBJ
Genomic DNA
M30308
EMBL· GenBank· DDBJ
AAA83533.1
EMBL· GenBank· DDBJ
Genomic DNA
X92982
EMBL· GenBank· DDBJ
CAA63563.1
EMBL· GenBank· DDBJ
Genomic DNA
X51797
EMBL· GenBank· DDBJ
CAA36093.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp