P10059 · HBA_SPHPU

Function

function

Involved in oxygen transport from the lung to the various peripheral tissues.

Miscellaneous

Sphenodon Hbs have properties not found in other reptiles: poor cooperativity, high affinity for oxygen, small Bohr and haldane effects, appreciable phosphate effects (those properties are also found in the Hbs of primitive urodele and caecilian amphibians).

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site58O2 (UniProtKB | ChEBI)
Binding site87Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); proximal binding residue

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthemoglobin complex
Molecular Functionheme binding
Molecular Functioniron ion binding
Molecular Functionoxygen binding
Molecular Functionoxygen carrier activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Hemoglobin subunit alpha-A
  • Alternative names
    • Alpha-A-globin
    • Hemoglobin alpha-A chain

Gene names

    • Name
      HBAA

Organism names

Accessions

  • Primary accession
    P10059

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000527671-141Hemoglobin subunit alpha-A

Expression

Tissue specificity

Red blood cells.

Interaction

Subunit

There are three forms of hemoglobin in Sphenodon: A, A' and D. Hb A is a tetramer of two alpha-A and two beta-1, Hb A' is a tetramer of two alpha-a and two beta-2, Hb D is a tetramer of two alpha-D and two beta-2.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-141Globin

Sequence similarities

Belongs to the globin family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    141
  • Mass (Da)
    15,454
  • Last updated
    1989-07-01 v1
  • Checksum
    F72D8BDD2D25C501
MLSASDKANVKAIWSKVCVHAEEYGAETLERMFTVYPSTKTYFPHFDLTHGSAQVKAHGKKVVNAMGEAVNHLDDMAGALLKLSDLHAQKLRVDPVNFKLLAQCFLVVLGVHHPAALTPEVHASLDKFLCAVGLVLTAKYR

Keywords

Sequence databases

Similar Proteins

Disclaimer

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