P0DI96 · OMP2B_BRUSS
- ProteinPorin Omp2b
- Geneomp2b
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids375 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Miscellaneous
The pore formed by Omp2a is larger than the one formed by Omp2b. Omp2b pores have optimal permeability to allow growth and protection against harmful compounds. The larger pore formed by Omp2a may be advantageous for intracellular growth, when the bacterium is competing with the host cell for nutrients whose concentration is particularly low within the phagosome.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cell outer membrane | |
Cellular Component | pore complex | |
Molecular Function | porin activity | |
Biological Process | monoatomic ion transport |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended namePorin Omp2b
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Brucellaceae > Brucella/Ochrobactrum group > Brucella
Accessions
- Primary accessionP0DI96
- Secondary accessions
Subcellular Location
UniProt Annotation
GO Annotation
Cell outer membrane ; Multi-pass membrane protein
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 59-60 | in strain: Fr7 | ||||
Sequence: VH → IS | ||||||
Natural variant | 75-77 | in strain: 686, De12, Fr7, Pt1 and Thomsen | ||||
Sequence: SGT → TGS | ||||||
Natural variant | 80 | in strain: Fr11 and Wf21 | ||||
Sequence: K → N | ||||||
Natural variant | 85 | in strain: De12, Fr7, Pt1 and Thomsen | ||||
Sequence: S → G | ||||||
Natural variant | 91-95 | in strain: De12, Fr7, Pt1 and Thomsen | ||||
Sequence: RVSTG → MFNTN | ||||||
Natural variant | 114-129 | in strain: 686, De12, Fr7, Fr11, Pt1, Thomsen and Wf21 | ||||
Sequence: SASNSREDGYYGTNSD → AANNSGVDGKYGNETSS | ||||||
Natural variant | 134 | in strain: 686, De12, Fr7, Fr11, Pt1, Thomsen and Wf21 | ||||
Sequence: Q → E | ||||||
Natural variant | 153 | in strain: 686, De12, Fr7, Fr11, Pt1, Thomsen and Wf21 | ||||
Sequence: Q → H | ||||||
Natural variant | 172 | in strain: 686, De12, Fr7, Fr11, Pt1, Thomsen and Wf21 | ||||
Sequence: T → S | ||||||
Natural variant | 206-222 | in strain: 686, De12, Fr7, Fr11, Pt1, Thomsen and Wf21 | ||||
Sequence: PVFKDSQGREINGRGYQ → GTTNYH | ||||||
Natural variant | 258 | in strain: 686, De12, Fr7, Fr11, Pt1, Thomsen and Wf21 | ||||
Sequence: T → A | ||||||
Natural variant | 339 | in strain: 686, De12, Fr7, Fr11, Pt1, Thomsen and Wf21 | ||||
Sequence: I → V | ||||||
Natural variant | 349-350 | in strain: 686, De12, Fr7, Fr11, Pt1, Thomsen and Wf21 | ||||
Sequence: SN → GG | ||||||
Natural variant | 354-363 | in strain: 686, De12, Fr7, Fr11, Pt1, Thomsen and Wf21 | ||||
Sequence: RELGNDTLDD → NTVAEDN |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 14 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MNIKSLLLGSAAALVAASGAQA | ||||||
Chain | PRO_0000412629 | 23-375 | Porin Omp2b | |||
Sequence: ADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYSGTDRKGWDKSARFALRVSTGSETELGTLKTFTELRFNYSASNSREDGYYGTNSDGTVMQFAYIQLGGLRVGIDESEFQTFTGYLGDVINDDVISAGTYRTGKISYTFTGGNGFSAVIALEQGGDNDGGYTPVFKDSQGREINGRGYQIDGYMPDVVGGLKYAGGWGSIAGVVAYDSVIEEWATKVRGDVNITDQFSVWLQGAYSSAATPDQNYGQWGGDWAVWGGLKYQATQKAAFNLQAAHDDWGKTAVTANVAYELVPGFTITPEVSYTKFSNEWKRELGNDTLDDAWGGIVRFQRSF |
Interaction
Subunit
Homotrimer.
Structure
Family & Domains
Domain
Consists of 16-stranded beta-barrel sheets, with large surface-exposed loops, that form a transmembrane pore at the center of each barrel. The pore is partially ocluded by a peptide loop that folds into the pore lumen.
Sequence similarities
Belongs to the alphaproteobacteria porin family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length375
- Mass (Da)40,569
- Last updated2011-09-21 v1
- Checksum539EB73D9B828DBB
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF268034 EMBL· GenBank· DDBJ | AAF80105.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY903259 EMBL· GenBank· DDBJ | AAX83995.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY903260 EMBL· GenBank· DDBJ | AAX83996.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY903261 EMBL· GenBank· DDBJ | AAX83997.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY903262 EMBL· GenBank· DDBJ | AAX83998.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY903263 EMBL· GenBank· DDBJ | AAX83999.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY903264 EMBL· GenBank· DDBJ | AAX84000.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY903265 EMBL· GenBank· DDBJ | AAX84001.1 EMBL· GenBank· DDBJ | Genomic DNA |