P0CU43 · CAHS3_HYPEX
- ProteinCytosolic-abundant heat soluble protein 77580
- GeneCAHS 77580
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids224 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
CAHS proteins are cytosolic heat soluble proteins that seem to contribute to the anhydrobiosis in tardigrades, but their specific mechanisms are yet to be identified (PubMed:28306513, PubMed:33545053).
It is possible that protection during anhydrobiosis might occur via the stabilization of vitrifying small molecules such as sugars, but not via the direct glass transition of CAHS proteins themselves (Probable)
It is possible that protection during anhydrobiosis might occur via the stabilization of vitrifying small molecules such as sugars, but not via the direct glass transition of CAHS proteins themselves (Probable)
Miscellaneous
Trehalose, a disaccharide essential for several organisms to survive drying, is detected at low levels or not at all in some tardigrade species, indicating that tardigrades possess potentially novel mechanisms for surviving desiccation involving tardigrade-specific intrinsically disordered proteins (TDPs) (PubMed:28306513).
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Biological Process | response to desiccation |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameCytosolic-abundant heat soluble protein 77580
- Short namesCAHS 77580
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Tardigrada > Eutardigrada > Parachela > Hypsibioidea > Hypsibiidae > Hypsibius
Accessions
- Primary accessionP0CU43
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Affects slightly survival under dry conditions but does not affect survival under frozen conditions (PubMed:28306513).
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000440192 | 1-224 | Cytosolic-abundant heat soluble protein 77580 | |||
Sequence: MSNYQQESSYQYSDRSNNGQQQEQQEKKEVEHSSYTHTDVKVNMPNLIAPFISSSAGLAQELVGEGFQASVSRITGASGELTVIDTEAETEEARRDMEAKAREQELLSRQFEKELERKTEAYRKQQEVETEKIRKELEKQHLRDVEFRKELMEQTIENQKRQIDLEARYAKKELERERNKVKRVLERSKFHTDIQVNMEAAAGSTHSGSSSVAVSESEKFQTNN |
Expression
Induction
Expression is highly induced during desiccation (PubMed:28306513).
Structure
Family & Domains
Features
Showing features for compositional bias, region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-20 | Polar residues | ||||
Sequence: MSNYQQESSYQYSDRSNNGQ | ||||||
Region | 1-38 | Disordered | ||||
Sequence: MSNYQQESSYQYSDRSNNGQQQEQQEKKEVEHSSYTHT | ||||||
Compositional bias | 21-36 | Basic and acidic residues | ||||
Sequence: QQEQQEKKEVEHSSYT | ||||||
Coiled coil | 83-191 | |||||
Sequence: VIDTEAETEEARRDMEAKAREQELLSRQFEKELERKTEAYRKQQEVETEKIRKELEKQHLRDVEFRKELMEQTIENQKRQIDLEARYAKKELERERNKVKRVLERSKFH | ||||||
Region | 122-140 | CAHS motif 1 | ||||
Sequence: YRKQQEVETEKIRKELEKQ | ||||||
Region | 159-177 | CAHS motif 2 | ||||
Sequence: QKRQIDLEARYAKKELERE | ||||||
Region | 200-224 | Disordered | ||||
Sequence: AAAGSTHSGSSSVAVSESEKFQTNN |
Domain
CAHS proteins contain 2 repeats of 19-mer peptides designated as CAHS-motifs that comprise each two octapeptides connected by a tripeptide (By similarity).
Sequence similarities
Belongs to the Cytosolic-abundant heat soluble protein (CAHS) family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length224
- Mass (Da)25,924
- Last updated2017-06-07 v1
- Checksum01BBA3EEFD1B37D7
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-20 | Polar residues | ||||
Sequence: MSNYQQESSYQYSDRSNNGQ | ||||||
Compositional bias | 21-36 | Basic and acidic residues | ||||
Sequence: QQEQQEKKEVEHSSYT |