P0CU43 · CAHS3_HYPEX

Function

function

CAHS proteins are cytosolic heat soluble proteins that seem to contribute to the anhydrobiosis in tardigrades, but their specific mechanisms are yet to be identified (PubMed:28306513, PubMed:33545053).
It is possible that protection during anhydrobiosis might occur via the stabilization of vitrifying small molecules such as sugars, but not via the direct glass transition of CAHS proteins themselves (Probable)

Miscellaneous

Trehalose, a disaccharide essential for several organisms to survive drying, is detected at low levels or not at all in some tardigrade species, indicating that tardigrades possess potentially novel mechanisms for surviving desiccation involving tardigrade-specific intrinsically disordered proteins (TDPs) (PubMed:28306513).

Caution

It was suggested that CAHS proteins were intrinsically unstructured and show heat-dependent glass transition, which contributes to the vitrification of cells, and this further leads to desiccation tolerance (PubMed:28306513).
However, more recent studies led to the conclusion that there was no evidence supporting glass transition of CAHS proteins to be contributing to the glass transition of the whole tardigrade (PubMed:33545053).

GO annotations

AspectTerm
Cellular Componentcytoplasm
Biological Processresponse to desiccation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytosolic-abundant heat soluble protein 77580
  • Short names
    CAHS 77580
  • Alternative names
    • Tardigrade-specific intrinsically disordered protein CAHS 77580
      (TDP CAHS 77580
      )

Gene names

    • Name
      CAHS 77580

Organism names

Accessions

  • Primary accession
    P0CU43

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Affects slightly survival under dry conditions but does not affect survival under frozen conditions (PubMed:28306513).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004401921-224Cytosolic-abundant heat soluble protein 77580

Expression

Induction

Expression is highly induced during desiccation (PubMed:28306513).

Structure

Family & Domains

Features

Showing features for compositional bias, region, coiled coil.

TypeIDPosition(s)Description
Compositional bias1-20Polar residues
Region1-38Disordered
Compositional bias21-36Basic and acidic residues
Coiled coil83-191
Region122-140CAHS motif 1
Region159-177CAHS motif 2
Region200-224Disordered

Domain

CAHS proteins contain 2 repeats of 19-mer peptides designated as CAHS-motifs that comprise each two octapeptides connected by a tripeptide (By similarity).

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    224
  • Mass (Da)
    25,924
  • Last updated
    2017-06-07 v1
  • Checksum
    01BBA3EEFD1B37D7
MSNYQQESSYQYSDRSNNGQQQEQQEKKEVEHSSYTHTDVKVNMPNLIAPFISSSAGLAQELVGEGFQASVSRITGASGELTVIDTEAETEEARRDMEAKAREQELLSRQFEKELERKTEAYRKQQEVETEKIRKELEKQHLRDVEFRKELMEQTIENQKRQIDLEARYAKKELERERNKVKRVLERSKFHTDIQVNMEAAAGSTHSGSSSVAVSESEKFQTNN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-20Polar residues
Compositional bias21-36Basic and acidic residues

Similar Proteins

Disclaimer

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