P0A4U3 · CADC_LACLL

Function

function

Metal-binding repressor for the cad operon. Involved in resistance to heavy metals, such as cadmium, bismuth, zinc or lead. Metal binding causes the repressor to dissociate from the DNA (By similarity).

Features

Showing features for binding site, dna binding.

1119102030405060708090100110
TypeIDPosition(s)Description
Binding site6Cd2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site10Cd2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site57Cd2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
DNA binding58-77H-T-H motif
Binding site59Cd2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionmetal ion binding
Biological Processresponse to cadmium ion

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cadmium resistance transcriptional regulatory protein CadC
  • Alternative names
    • Cadmium efflux system accessory protein

Gene names

    • Name
      cadC

Encoded on

  • Plasmid pND302
  • Plasmid pAH82

Organism names

Accessions

  • Primary accession
    P0A4U3
  • Secondary accessions
    • P94887

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001606171-119Cadmium resistance transcriptional regulatory protein CadC

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain23-118HTH arsR-type

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    119
  • Mass (Da)
    13,382
  • Last updated
    2005-03-15 v1
  • Checksum
    B34C01C21DC2C944
MNNEICEITCIHEDKVNRAKSKLANFDTPSVSGFFKILSDENRLKIVHALVHEDELCVCDIANIIDASVATTSHHLNSLKKLGVVDSHKDGKLVYYFIKNIKILNLMELGVNFKEEVLA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U78967
EMBL· GenBank· DDBJ
AAB37344.1
EMBL· GenBank· DDBJ
Genomic DNA
AF243383
EMBL· GenBank· DDBJ
AAF98301.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp