P06398 · TNNT3_COTJA
- ProteinTroponin T, fast skeletal muscle isoforms
- GeneTNNT3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids253 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | troponin complex | |
Molecular Function | tropomyosin binding | |
Molecular Function | troponin C binding | |
Molecular Function | troponin I binding | |
Biological Process | regulation of muscle contraction | |
Biological Process | sarcomere organization | |
Biological Process | skeletal muscle contraction |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameTroponin T, fast skeletal muscle isoforms
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Perdicinae > Coturnix
Accessions
- Primary accessionP06398
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylserine | ||||
Sequence: S | ||||||
Chain | PRO_0000186184 | 2-253 | Troponin T, fast skeletal muscle isoforms | |||
Sequence: SDTEEVEHGEEEYEEEEEVQEEEVHEPAPPPEEKPRIKLTAPKIPEGEKVDFDDIQKKRQNKDLIELQALIDSHFEARRKEEEELVALKERIEKRRAERAEQQRIRAEKEKERQARLAEEKARREEEDAKRKAEDDLKKKKALSSMGASYSSYLAKADQKRGKKQTARETKKKVLAERRKPLNIDHLNEDKLRDKAKELWDWLYQLQTEKYDFTEQIKRKKYEILTLRCRLQELSKFSKKAGAKGKVGGRWK |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-24 | Acidic residues | ||||
Sequence: MSDTEEVEHGEEEYEEEEEVQEEE | ||||||
Region | 1-58 | Disordered | ||||
Sequence: MSDTEEVEHGEEEYEEEEEVQEEEVHEPAPPPEEKPRIKLTAPKIPEGEKVDFDDIQK | ||||||
Compositional bias | 25-58 | Basic and acidic residues | ||||
Sequence: VHEPAPPPEEKPRIKLTAPKIPEGEKVDFDDIQK | ||||||
Compositional bias | 97-143 | Basic and acidic residues | ||||
Sequence: RAERAEQQRIRAEKEKERQARLAEEKARREEEDAKRKAEDDLKKKKA | ||||||
Region | 97-178 | Disordered | ||||
Sequence: RAERAEQQRIRAEKEKERQARLAEEKARREEEDAKRKAEDDLKKKKALSSMGASYSSYLAKADQKRGKKQTARETKKKVLAE | ||||||
Compositional bias | 158-178 | Basic and acidic residues | ||||
Sequence: ADQKRGKKQTARETKKKVLAE |
Sequence similarities
Belongs to the troponin T family.
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing. Additional isoforms seem to exist.
P06398-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length253
- Mass (Da)30,098
- Last updated2007-01-23 v4
- Checksum5E37D1A587FAC997
P06398-2
- Name2
- Differences from canonical
- 28-31: Missing
P06398-3
- Name3
- Differences from canonical
- 226-238: LTLRCRLQELSKF → VTLRNRIDQAQKH
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-24 | Acidic residues | ||||
Sequence: MSDTEEVEHGEEEYEEEEEVQEEE | ||||||
Compositional bias | 25-58 | Basic and acidic residues | ||||
Sequence: VHEPAPPPEEKPRIKLTAPKIPEGEKVDFDDIQK | ||||||
Alternative sequence | VSP_006637 | 28-31 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 97-143 | Basic and acidic residues | ||||
Sequence: RAERAEQQRIRAEKEKERQARLAEEKARREEEDAKRKAEDDLKKKKA | ||||||
Compositional bias | 158-178 | Basic and acidic residues | ||||
Sequence: ADQKRGKKQTARETKKKVLAE | ||||||
Alternative sequence | VSP_006638 | 226-238 | in isoform 3 | |||
Sequence: LTLRCRLQELSKF → VTLRNRIDQAQKH |
Keywords
- Coding sequence diversity
- Technical term