P06398 · TNNT3_COTJA

Function

function

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenttroponin complex
Molecular Functiontropomyosin binding
Molecular Functiontroponin C binding
Molecular Functiontroponin I binding
Biological Processregulation of muscle contraction
Biological Processsarcomere organization
Biological Processskeletal muscle contraction

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Troponin T, fast skeletal muscle isoforms

Gene names

    • Name
      TNNT3

Organism names

Accessions

  • Primary accession
    P06398
  • Secondary accessions
    • P06397

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylserine
ChainPRO_00001861842-253Troponin T, fast skeletal muscle isoforms

Keywords

Structure

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-24Acidic residues
Region1-58Disordered
Compositional bias25-58Basic and acidic residues
Compositional bias97-143Basic and acidic residues
Region97-178Disordered
Compositional bias158-178Basic and acidic residues

Sequence similarities

Belongs to the troponin T family.

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing. Additional isoforms seem to exist.

P06398-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    253
  • Mass (Da)
    30,098
  • Last updated
    2007-01-23 v4
  • Checksum
    5E37D1A587FAC997
MSDTEEVEHGEEEYEEEEEVQEEEVHEPAPPPEEKPRIKLTAPKIPEGEKVDFDDIQKKRQNKDLIELQALIDSHFEARRKEEEELVALKERIEKRRAERAEQQRIRAEKEKERQARLAEEKARREEEDAKRKAEDDLKKKKALSSMGASYSSYLAKADQKRGKKQTARETKKKVLAERRKPLNIDHLNEDKLRDKAKELWDWLYQLQTEKYDFTEQIKRKKYEILTLRCRLQELSKFSKKAGAKGKVGGRWK

P06398-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

P06398-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 226-238: LTLRCRLQELSKF → VTLRNRIDQAQKH

Features

Showing features for compositional bias, alternative sequence.

TypeIDPosition(s)Description
Compositional bias1-24Acidic residues
Compositional bias25-58Basic and acidic residues
Alternative sequenceVSP_00663728-31in isoform 2
Compositional bias97-143Basic and acidic residues
Compositional bias158-178Basic and acidic residues
Alternative sequenceVSP_006638226-238in isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M26600
EMBL· GenBank· DDBJ
AAA49506.1
EMBL· GenBank· DDBJ
mRNA
M26599
EMBL· GenBank· DDBJ
AAA49505.1
EMBL· GenBank· DDBJ
mRNA
M11685
EMBL· GenBank· DDBJ
AAA49504.1
EMBL· GenBank· DDBJ
mRNA
M11684
EMBL· GenBank· DDBJ
AAA49503.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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