P00627 · PA2B6_BUNFA

Function

function

Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Very weakly suppress the acetylcholine (ACh)-evoked current mediated by alpha-7-similar nAChRs in L.stagnalis neurons.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site43Ca2+ (UniProtKB | ChEBI)
Binding site45Ca2+ (UniProtKB | ChEBI)
Binding site47Ca2+ (UniProtKB | ChEBI)
Active site63
Binding site64Ca2+ (UniProtKB | ChEBI)
Active site109

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functioncalcium ion binding
Molecular Functioncalcium-dependent phospholipase A2 activity
Molecular Functionphospholipid binding
Molecular Functiontoxin activity
Biological Processarachidonic acid secretion
Biological Processlipid catabolic process
Biological Processphospholipid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Basic phospholipase A2 6
  • EC number
  • Short names
    svPLA2
  • Alternative names
    • KBf VI
    • KBf-6
    • Phosphatidylcholine 2-acylhydrolase
    • Phospholipase A2 isozyme VI
    • Toxin VI

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Elapidae > Bungarinae > Bungarus

Accessions

  • Primary accession
    P00627
  • Secondary accessions
    • A2CIZ7

Subcellular Location

Keywords

Phenotypes & Variants

Toxic dose

LD50 is 3.6 mg/kg by intraperitoneal injection.

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant104
Natural variant129

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for propeptide, signal, chain, disulfide bond.

TypeIDPosition(s)Description
PropeptidePRO_0000291950?-17
Signal1-?
ChainPRO_000016163818-135Basic phospholipase A2 6
Disulfide bond28↔87
Disulfide bond42↔134
Disulfide bond44↔60
Disulfide bond59↔115
Disulfide bond66↔108
Disulfide bond76↔101
Disulfide bond94↔106

Keywords

Expression

Tissue specificity

Expressed by the venom gland.

Structure

Family & Domains

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    135
  • Mass (Da)
    14,701
  • Last updated
    2007-06-26 v3
  • Checksum
    70D5C24E5297B2CC
AVCVSLLGAANIPPQSLNLYQFKNMIECAGTRTWLAYVKYGCYCGPGGTGTPLDELDRCCQTHDHCYDNAKKFGNCIPYLKTYVYTCNKPDITCTGAKGSCGRNVCDCDRAAAICFAAAPYNLANFGIDKEKHCQ

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Mass Spectrometry

Molecular mass is 13,051 Da. Determined by Electrospray.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ508406
EMBL· GenBank· DDBJ
ABG74585.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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