O87796 · ALF_STUST

Function

function

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit. One is catalytic and the other provides a structural contribution.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site50D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Active site83Proton donor
Binding site84Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site105Zn2+ 2 (UniProtKB | ChEBI)
Binding site142Zn2+ 2 (UniProtKB | ChEBI)
Binding site198Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site199dihydroxyacetone phosphate (UniProtKB | ChEBI)
Binding site232Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site233-235dihydroxyacetone phosphate (UniProtKB | ChEBI)
Binding site275-278dihydroxyacetone phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionfructose-bisphosphate aldolase activity
Molecular Functionzinc ion binding
Biological Processglycolytic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fructose-bisphosphate aldolase
  • EC number
  • Short names
    FBP aldolase; FBPA
  • Alternative names
    • Fructose-1,6-bisphosphate aldolase

Gene names

    • Name
      fba
    • Synonyms
      fda

Organism names

Accessions

  • Primary accession
    O87796

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001787261-354Fructose-bisphosphate aldolase

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    354
  • Mass (Da)
    38,350
  • Last updated
    1998-11-01 v1
  • Checksum
    18922C53CB21A5E9
MALISMRQMLDHAAEFGYGVPAFNVNNLEQMRAIMEAADKTDSPVIVQASAGARKYAGAPFLRHLILAAIEEFPHIPVCMHQDHGTSPDVCQRSIQLGFSSVMMDGSLREDGKTPADYDYNVRVTQQTVAFAHACGVSVEGELGCLGSLETGMAGEEDGVGAEGVLDHSQLLTDPEEAADFVAKTKVDALAIAIGTSHGAYKFTNPPTGDTLSIQRIKEIHARIPDTHLVMHGSSSVPQEWLKIINEYGGEIGETYGVPVEEIVEGIKYGVRKVNIDTDLRLASTGAIREFLAKNPSEFDPRKYFAKTVAAMRDICIARYEAFGTAGNASKIKPISLEGMFQRYASGELDPKIN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ011927
EMBL· GenBank· DDBJ
CAA09871.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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