O84947 · SCTE2_SALTY

Function

function

Component of the type III secretion system 2 (SPI-2 T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (Probable). SseC/SctE2 and SseD/SctB2 are inserted into the host membrane where they form a pore and allow the translocation of effector proteins into the cytosol of target cells (Probable).
Required for the translocation of SPI-2 effector proteins (PubMed:11567004).
Required for systemic Salmonella infection of the mouse (PubMed:11159962).
Essential for SpvB-induced actin depolymerization in the host cell cytoplasm (PubMed:18248436).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentcytoplasm
Cellular Componentextracellular region
Cellular Componenthost cell membrane
Cellular Componentmembrane
Molecular Functionprotein-folding chaperone binding
Biological Processprotein secretion by the type III secretion system

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    SPI-2 type 3 secretion system translocon protein SctE
  • Short names
    SPI-2 T3SS translocon protein SctE
  • Alternative names
    • Secreted effector protein SseC
    • Secretion system effector C

Gene names

    • Name
      sctE2
    • Synonyms
      sseC
    • Ordered locus names
      STM1400

Organism names

Accessions

  • Primary accession
    O84947
  • Secondary accessions
    • Q2I3D0
    • Q7CQL9
    • Q9R804

Proteomes

Subcellular Location

Secreted
Cell surface
Host membrane
; Multi-pass membrane protein
Note: Secreted via the type III secretion system 2 (SPI-2 T3SS) (PubMed:11159962, PubMed:11567004).
After secretion, localizes mainly on the surface of the bacterial cell (PubMed:11159962, PubMed:11567004).

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane85-105Helical
Transmembrane152-172Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Mutant is severely attenuated in virulence (PubMed:9786193).
Disruption prevents SpvB-induced F-actin depolymerization in human macrophages without affecting intra-bacterial SpvB protein levels (PubMed:18248436).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003917161-484SPI-2 type 3 secretion system translocon protein SctE

Proteomic databases

Interaction

Subunit

The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (PubMed:30107569).
This subunit is involved in the formation of a pore, called the translocon, in host membrane (Probable). May form a complex with SseB and SseD/SctB2 (PubMed:11567004).
SseB is required for correct localization of SseC/SctE2 on the bacterial cell surface (PubMed:11567004).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for coiled coil.

TypeIDPosition(s)Description
Coiled coil107-152
Coiled coil413-457

Sequence similarities

Belongs to the SctE/SipB/YopB family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    484
  • Mass (Da)
    52,777
  • Last updated
    1998-11-01 v1
  • Checksum
    14C40E43A0699285
MNRIHSNSDSAAGVTALTHHHLSNVSCVSSGSLGKRQHRVNSTFGDGNAACLLSGKISLQEASNALKQLLDAVPGNHKRPSLPDFLQTNPAVLSMMMTSLILNVFGNNAQSLCQQLERATEVQNALRNKQVKEYQEQIQKAIEQEDKARKAGIFGAIFDWITGIFETVIGALKVVEGFLSGNPAEMASGVAYMAAGCAGMVKAGAETAMMCGADHDTCQAIIDVTSKIQFGCEAVALALDVFQIGRAFMATRGLSGAAAKVLDSGFGEEVVERMVGAGEAEIEELAEKFGEEVSESFSKQFEPLEREMAMANEMAEEAAEFSRNVENNMTRSAGKSFTKEGVKAMAKEAAKEALEKCVQEGGKFLLKKFRNKVLFNMFKKILYALLRDCSFKGLQAIRCATEGASQMNTGMVNTEKAKIEKKIEQLITQQRFLDFIMQQTENQKKIEQKRLEELYKGSGAALRDVLDTIDHYSSVQARIAGYRA

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict458in Ref. 1; CAA12187

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ224892
EMBL· GenBank· DDBJ
CAA12187.1
EMBL· GenBank· DDBJ
Genomic DNA
AF020808
EMBL· GenBank· DDBJ
AAC28881.1
EMBL· GenBank· DDBJ
Genomic DNA
AE006468
EMBL· GenBank· DDBJ
AAL20324.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ320510
EMBL· GenBank· DDBJ
ABC59204.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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