O61303 · OPSUV_APIME
- ProteinOpsin, ultraviolet-sensitive
- GeneUVOP
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids371 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to 11-cis-retinal.
Absorption
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | G protein-coupled photoreceptor activity | |
Molecular Function | photoreceptor activity | |
Biological Process | cellular response to light stimulus | |
Biological Process | phototransduction | |
Biological Process | visual perception |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameOpsin, ultraviolet-sensitive
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Hymenoptera > Apocrita > Aculeata > Apoidea > Anthophila > Apidae > Apis
Accessions
- Primary accessionO61303
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-52 | Extracellular | ||||
Sequence: MSNDSIHWEARYLPAGPPRLLGWNVPAEELIHIPEHWLVYPEPNPSLHYLLA | ||||||
Transmembrane | 53-73 | Helical; Name=1 | ||||
Sequence: LLYILFTFLALLGNGLVIWIF | ||||||
Topological domain | 74-84 | Cytoplasmic | ||||
Sequence: CAAKSLRTPSN | ||||||
Transmembrane | 85-105 | Helical; Name=2 | ||||
Sequence: MFVVNLAICDFFMMIKTPIFI | ||||||
Topological domain | 106-121 | Extracellular | ||||
Sequence: YNSFNTGFALGNLGCQ | ||||||
Transmembrane | 122-142 | Helical; Name=3 | ||||
Sequence: IFAVIGSLTGIGAAITNAAIA | ||||||
Topological domain | 143-161 | Cytoplasmic | ||||
Sequence: YDRYSTIARPLDGKLSRGQ | ||||||
Transmembrane | 162-182 | Helical; Name=4 | ||||
Sequence: VILFIVLIWTYTIPWALMPVM | ||||||
Topological domain | 183-209 | Extracellular | ||||
Sequence: GVWGRFVPEGFLTSCSFDYLTDTNEIR | ||||||
Transmembrane | 210-230 | Helical; Name=5 | ||||
Sequence: IFVATIFTFSYCIPMILIIYY | ||||||
Topological domain | 231-278 | Cytoplasmic | ||||
Sequence: YSQIVSHVVNHEKALREQAKKMNVDSLRSNANTSSQSAEIRIAKAAIT | ||||||
Transmembrane | 279-299 | Helical; Name=6 | ||||
Sequence: ICFLYVLSWTPYGVMSMIGAF | ||||||
Topological domain | 300-302 | Extracellular | ||||
Sequence: GNK | ||||||
Transmembrane | 303-323 | Helical; Name=7 | ||||
Sequence: ALLTPGVTMIPACTCKAVACL | ||||||
Topological domain | 324-371 | Cytoplasmic | ||||
Sequence: DPYVYAISHPKYRLELQKRLPWLELQEKPISDSTSTTTETVNTPPASS |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000197639 | 1-371 | Opsin, ultraviolet-sensitive | |||
Sequence: MSNDSIHWEARYLPAGPPRLLGWNVPAEELIHIPEHWLVYPEPNPSLHYLLALLYILFTFLALLGNGLVIWIFCAAKSLRTPSNMFVVNLAICDFFMMIKTPIFIYNSFNTGFALGNLGCQIFAVIGSLTGIGAAITNAAIAYDRYSTIARPLDGKLSRGQVILFIVLIWTYTIPWALMPVMGVWGRFVPEGFLTSCSFDYLTDTNEIRIFVATIFTFSYCIPMILIIYYYSQIVSHVVNHEKALREQAKKMNVDSLRSNANTSSQSAEIRIAKAAITICFLYVLSWTPYGVMSMIGAFGNKALLTPGVTMIPACTCKAVACLDPYVYAISHPKYRLELQKRLPWLELQEKPISDSTSTTTETVNTPPASS | ||||||
Glycosylation | 3 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 120↔197 | |||||
Sequence: CQIFAVIGSLTGIGAAITNAAIAYDRYSTIARPLDGKLSRGQVILFIVLIWTYTIPWALMPVMGVWGRFVPEGFLTSC | ||||||
Modified residue | 318 | N6-(retinylidene)lysine | ||||
Sequence: K |
Post-translational modification
Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in the dorsal region of the retina.
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length371
- Mass (Da)41,458
- Last updated1998-08-01 v1
- Checksum9B2BB1FF92762956
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF004169 EMBL· GenBank· DDBJ | AAC13418.1 EMBL· GenBank· DDBJ | mRNA | ||
AADG06009813 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BK005513 EMBL· GenBank· DDBJ | DAA05738.1 EMBL· GenBank· DDBJ | Genomic DNA |