O42633 · FAT1_COCHE

Function

function

Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.

Catalytic activity

Features

Showing features for binding site.

164350100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site235-246ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentlipid droplet
Cellular Componentperoxisomal membrane
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionlong-chain fatty acid transmembrane transporter activity
Molecular Functionlong-chain fatty acid-CoA ligase activity
Molecular Functionvery long-chain fatty acid-CoA ligase activity
Biological Processlong-chain fatty acid import into cell
Biological Processvery long-chain fatty acid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Very long-chain fatty acid transport protein
  • EC number
  • Alternative names
    • Very-long-chain acyl-CoA synthetase (VLCS)

Gene names

    • Name
      FAT1

Organism names

Accessions

  • Primary accession
    O42633

Subcellular Location

Lipid droplet
Cell membrane
; Multi-pass membrane protein
Peroxisome membrane
; Multi-pass membrane protein
Peroxisome

Features

Showing features for topological domain, transmembrane, intramembrane.

TypeIDPosition(s)Description
Topological domain1-15Cytoplasmic
Transmembrane16-36Helical
Topological domain37-138Extracellular
Transmembrane139-159Helical
Topological domain160-249Cytoplasmic
Intramembrane250-318
Topological domain319-643Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001931801-643Very long-chain fatty acid transport protein

Structure

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif477-525FACS

Domain

The FACS motif is required for catalytic activity and substrate specificity.

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    643
  • Mass (Da)
    72,311
  • Last updated
    1998-06-01 v1
  • Checksum
    0CAF3129C0D7B43C
MACMHQAQLYNDLEELLTGPSVPIVAGAAGAAALTAYINAKYHIAHDLKTLGGGLTQSSEAIDFINRRVAQKRVLTHHIFQEQVQKQSNHPFLIFEGKTWSYKEFSEAYTRVANWLIDELDVQVGEMVAIDGGNSAEHLMLWLALDAIGAATSFLNWNLTGAGLIHCIKLCECRFVIADIDIKANIEPCRGELEETGINIHYYDPSFISSLPNNTPIPDSRTENIELDSVRGLIYTSGTTGLPKGVFISTGRELRTDWSISKYLNLKPTDRMYTCMPLYHAAAHSLCTASVIHGGGTVVLSRKFSHKKFWPEVVASEANIIQYVGELGRYLLNGPKSPYDRAHKVQMAWGNGMRPDVWEAFRERFNIPIIHELYAATDGLGSMTNRNAGPFTANCIALRGLIWHWKFRNQEVLVKMDLDTDEIMRDRNGFAIRCAVNEPGQMLFRLTPETLAGAPSYYNNETATQSRRITDVFQKGDLWFKSGDMLRQDAEGRVYFVDRLGDTFRWKSENVSTNEVADVMGTFPQIAETNVYGVLVPGNDGRVRSLNCHGRRRDRVDIRFAALAKHARDRLPGYAVPLFLRVTPALEYTGTLKIQKGRLKQEGIDPDKISGEDKLYWLPPGSDIYLPFGKMEWQGIVDKRIRL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y15839
EMBL· GenBank· DDBJ
CAA75802.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp