O32434 · CGOX_PROFF
- ProteinCoproporphyrinogen III oxidase
- GenecgoX
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids527 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.
Catalytic activity
- coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 FAD per subunit.
Pathway
Porphyrin-containing compound metabolism; protoheme biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 33-38 | FAD (UniProtKB | ChEBI) | ||||
Sequence: GGGITG | ||||||
Binding site | 56-57 | FAD (UniProtKB | ChEBI) | ||||
Sequence: ES | ||||||
Binding site | 64 | FAD (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 78-81 | FAD (UniProtKB | ChEBI) | ||||
Sequence: GPDS | ||||||
Binding site | 300 | FAD (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 448 | FAD (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 487-489 | FAD (UniProtKB | ChEBI) | ||||
Sequence: VGL |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | oxygen-dependent protoporphyrinogen oxidase activity | |
Biological Process | heme biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCoproporphyrinogen III oxidase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Propionibacteriales > Propionibacteriaceae > Propionibacterium
Accessions
- Primary accessionO32434
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000135268 | 1-527 | Coproporphyrinogen III oxidase | |||
Sequence: MSTTDRVTTPTPTVSGTDAPGPDASHCHLVVVGGGITGLAAAWQGMARGARVSVVESDDHFGGKVVTDRRDGFLVEQGPDSFVAYRPAALKLIEELGLSDQVIAPGGGRRVSLLSRGKLRPMPAGMGMVLPTRMWPFVTTTVLSWPDKIRAGLDLVIPRRLPDHDVAIGAFLRQRLGDGIVRRFADPMVGGIYGAGIDELSLDAVLPSLRDNERDHRSLMVASLAGGRASRRAARQRAAQNNAQQNSSHQNSTGQNNSAGTRGPAASPFRTLRGGLGQLIDALVDQLRAGGVELLVNTSVDLLGRDGVHLSDGRVLPADAVVLAGGVASSARLLRPQLPAAARALAQIPLASTTIVSLAWPVSAFDVAPDSQGWLEADAGPVSGLTASSIKFAGRAPDGSVLMRVFVPDKRGPLTDAPDDELLSAVIDHVRPLLGVHGEPGLTQITRWHKVMPKYTVGHLERAAVVDSTLAEQRPTWAVAGSALHGVGLPDCISDARHSADEVIDAALAATPSAPNRNAATDRTETR |
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-18 | Polar residues | ||||
Sequence: MSTTDRVTTPTPTVSGTD | ||||||
Region | 1-23 | Disordered | ||||
Sequence: MSTTDRVTTPTPTVSGTDAPGPD | ||||||
Region | 231-267 | Disordered | ||||
Sequence: RRAARQRAAQNNAQQNSSHQNSTGQNNSAGTRGPAAS | ||||||
Compositional bias | 235-264 | Polar residues | ||||
Sequence: RQRAAQNNAQQNSSHQNSTGQNNSAGTRGP |
Sequence similarities
Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length527
- Mass (Da)55,268
- Last updated1998-01-01 v1
- Checksum579CB0A3318BF938
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-18 | Polar residues | ||||
Sequence: MSTTDRVTTPTPTVSGTD | ||||||
Compositional bias | 235-264 | Polar residues | ||||
Sequence: RQRAAQNNAQQNSSHQNSTGQNNSAGTRGP |