O32177 · FADA_BACSU
- Protein3-ketoacyl-CoA thiolase
- GenefadA
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids391 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Involved in the degradation of long-chain fatty acids.
Catalytic activity
- acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA
Pathway
Lipid metabolism; fatty acid beta-oxidation.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 90 | Acyl-thioester intermediate | ||||
Sequence: C | ||||||
Active site | 347 | Proton acceptor | ||||
Sequence: H | ||||||
Active site | 377 | Proton acceptor | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | acetyl-CoA C-acyltransferase activity | |
Biological Process | fatty acid beta-oxidation | |
Biological Process | phenylacetate catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-ketoacyl-CoA thiolase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Bacillus
Accessions
- Primary accessionO32177
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000360669 | 1-391 | 3-ketoacyl-CoA thiolase | |||
Sequence: MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGGYEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAEKIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGVSREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGVRPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRSFAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEEKVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC |
Proteomic databases
Expression
Induction
Repressed by FadR in the absence of LCFAs (fatty acids of 14-20 carbon atoms). When LCFAs are present in the medium, they are converted to long-chain acyl-CoAs, which antagonize FadR as to its binding to fadR boxes on target DNA and thus derepress transcription.
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length391
- Mass (Da)41,123
- Last updated1998-01-01 v1
- ChecksumB326A3D6A64E5799
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL009126 EMBL· GenBank· DDBJ | CAB15272.1 EMBL· GenBank· DDBJ | Genomic DNA |