O21001 · NU2M_BRALA

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological Processmitochondrial electron transport, NADH to ubiquinone

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 2
  • EC number
  • Alternative names
    • NADH dehydrogenase subunit 2

Gene names

    • Name
      ND2
    • Synonyms
      NAD2, NADH2

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    O21001
  • Secondary accessions
    • O79416

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane1-21Helical
Transmembrane26-46Helical
Transmembrane60-80Helical
Transmembrane96-116Helical
Transmembrane122-142Helical
Transmembrane151-171Helical
Transmembrane178-198Helical
Transmembrane199-219Helical
Transmembrane242-262Helical
Transmembrane274-294Helical
Transmembrane320-340Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001175611-346NADH-ubiquinone oxidoreductase chain 2

Structure

Family & Domains

Sequence similarities

Belongs to the complex I subunit 2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    346
  • Mass (Da)
    37,371
  • Last updated
    1998-12-15 v2
  • Checksum
    73E1715D0BE5D824
MSPYISPLFSITMIMSVMLISSSGHWVFMWLGLELGTLAFIPILVWWHSSLEVEATVKYFIVQAMAAAVFFLGGMVSLSGDFMGGVNQLMGNIGDMMIMLAVVTKLGLAPFHYWVVDVVQGLNYIPGAVLLTWQKVPGLAVLTQLATCNNSSMLLLFGMVSALVGGLGGLGQTQMRKLLAFSSISHLGWLVVGCVAGSLLGLSYFTLYVILSIPLFSILHMLNGGHLNQLRTGLMFNPLMSVLLGVGFLSLGGLPPFFGFFGKWLLLTHFVGQLLLGVSVVLITGTLISLFYYLRVSYLCIVVLGPQQIMSGLNWRKMQLSGLMSGLLVLNMLGLFLVGGASCLPK

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict79in Ref. 1; CAA70709
Sequence conflict92in Ref. 1; CAA70709
Sequence conflict157in Ref. 1; CAA70709
Sequence conflict191in Ref. 1; CAA70709
Sequence conflict199in Ref. 1; CAA70709
Sequence conflict210in Ref. 1; CAA70709
Sequence conflict229in Ref. 1; CAA70709

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y09524
EMBL· GenBank· DDBJ
CAA70709.1
EMBL· GenBank· DDBJ
Genomic DNA
Y16474
EMBL· GenBank· DDBJ
CAA76248.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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