O05097 · ATP6_CLOAB
- ProteinATP synthase subunit a
- GeneatpB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids221 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | proton-transporting ATP synthase complex, coupling factor F(o) | |
Molecular Function | proton-transporting ATP synthase activity, rotational mechanism | |
Biological Process | proton motive force-driven plasma membrane ATP synthesis |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameATP synthase subunit a
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium
Accessions
- Primary accessionO05097
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 20-40 | Helical | ||||
Sequence: ITETVVLQWIIMAVIILLAIF | ||||||
Transmembrane | 78-98 | Helical | ||||
Sequence: FVPIIGTMAVFILFLNLTGLV | ||||||
Transmembrane | 106-126 | Helical | ||||
Sequence: DISVTAGFALVSAFLINATAI | ||||||
Transmembrane | 158-178 | Helical | ||||
Sequence: VSLCLRLFINMLVGAIVMSLI | ||||||
Transmembrane | 194-214 | Helical | ||||
Sequence: FFDMFDGVLQVYVFVLLTMIF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000082052 | 1-221 | ATP synthase subunit a | |||
Sequence: MELGAKTVFSMKLGSYNFAITETVVLQWIIMAVIILLAIFLTKNLKKVPNRKQSVIEMIVNLINGLVKENMGEKFMNFVPIIGTMAVFILFLNLTGLVGIEPATKDISVTAGFALVSAFLINATAIKRIGVGGYIKSIFSQGPIMVPMNLLEKVTIPVSLCLRLFINMLVGAIVMSLIYSTPAKILLPVPLHGFFDMFDGVLQVYVFVLLTMIFTKLGIEH |
Interaction
Subunit
F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length221
- Mass (Da)24,316
- Last updated1997-07-01 v1
- Checksum391D05175396C3EA
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U52367 EMBL· GenBank· DDBJ | AAB50191.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF101055 EMBL· GenBank· DDBJ | AAD16420.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE001437 EMBL· GenBank· DDBJ | AAK80814.1 EMBL· GenBank· DDBJ | Genomic DNA |