N0E1H3 · N0E1H3_9MICO

Function

function

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
    EC:3.4.11.1 (UniProtKB | ENZYME | Rhea)
  • Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.
    EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site258Mn2+ 2 (UniProtKB | ChEBI)
Binding site263Mn2+ 1 (UniProtKB | ChEBI)
Binding site263Mn2+ 2 (UniProtKB | ChEBI)
Active site270
Binding site281Mn2+ 2 (UniProtKB | ChEBI)
Binding site340Mn2+ 1 (UniProtKB | ChEBI)
Binding site342Mn2+ 1 (UniProtKB | ChEBI)
Binding site342Mn2+ 2 (UniProtKB | ChEBI)
Active site344

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmanganese ion binding
Molecular Functionmetalloaminopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable cytosol aminopeptidase
  • EC number
  • Alternative names
    • Leucine aminopeptidase
      (LAP
      ) (EC:3.4.11.10
      ) . EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)
    • Leucyl aminopeptidase

Gene names

    • Name
      pepA
    • ORF names
      BN10_290004

Organism names

  • Taxonomic identifier
  • Strain
    • Lp2
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Intrasporangiaceae > Phycicoccus

Accessions

  • Primary accession
    N0E1H3

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain38-134Peptidase M17 leucyl aminopeptidase N-terminal
Domain176-484Cytosol aminopeptidase

Sequence similarities

Belongs to the peptidase M17 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    491
  • Mass (Da)
    49,510
  • Last updated
    2013-06-26 v1
  • Checksum
    5D8B77C14540E0EB
MPTLTVTTRTPADIAADSVVVASIEGKDGALLAPGHGLPSTAAVHLEAMLADLDAKGSAGEVGRFASVPGVKARSVTVTGLGKEVTGEALRAAAADAVRALRSKKHVVLALPTADLTALAAAADGAAGGGYCFAKIGAKADTTAVQKITVVSTLGAGKGVKDAVARAEVIGRARDWTRDLVNTPPNVLYPASFEAAAKDRAKASPAKVTVTSLDEKALAKGGFGGIVGVGQGSANPPRIVTMSWKPAKAKASIALVGKGITFDSGGLCIKPSAGMLTMKSDMAGAAAVAAAVMAAAELDLPVAVTGYLCLAENMPSGTAQRPSDVVTMRNRSTVEIIDTDAEGRMVLGDGLCLAAEKKPDAIIDIATLTGAQMVALGNLVAGVMANDDSFRDRVVLAGATAGEPSWPMPLPESLRKGLESQTADIAHKADRWGGMLTAGLFLSTFVPEGTPWAHIDIAGPSFNEGGPLGMAPKGGTGYGVASLVALIEQYA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAIZ01000096
EMBL· GenBank· DDBJ
CCH69636.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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