M9YBC3 · M9YBC3_AZOVI
- ProteinHistidinol dehydrogenase
- GenehisD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids436 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Catalytic activity
- L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 3 H+
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 136 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 197 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 220 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 243 | substrate | ||||
Sequence: S | ||||||
Binding site | 265 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 265 | substrate | ||||
Sequence: Q | ||||||
Binding site | 268 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 268 | substrate | ||||
Sequence: H | ||||||
Active site | 333 | Proton acceptor | ||||
Sequence: E | ||||||
Active site | 334 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 334 | substrate | ||||
Sequence: H | ||||||
Binding site | 367 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 367 | substrate | ||||
Sequence: D | ||||||
Binding site | 421 | substrate | ||||
Sequence: E | ||||||
Binding site | 426 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 426 | substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | histidinol dehydrogenase activity | |
Molecular Function | NAD binding | |
Molecular Function | zinc ion binding | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistidinol dehydrogenase
- EC number
- Short namesHDH
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Azotobacter
Accessions
- Primary accessionM9YBC3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Sequence
- Sequence statusComplete
- Length436
- Mass (Da)47,154
- Last updated2013-06-26 v1
- Checksum5670516359A6DD6E
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP005095 EMBL· GenBank· DDBJ | AGK18080.1 EMBL· GenBank· DDBJ | Genomic DNA |