M9YBC3 · M9YBC3_AZOVI

Function

function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site136NAD+ (UniProtKB | ChEBI)
Binding site197NAD+ (UniProtKB | ChEBI)
Binding site220NAD+ (UniProtKB | ChEBI)
Binding site243substrate
Binding site265Zn2+ (UniProtKB | ChEBI)
Binding site265substrate
Binding site268Zn2+ (UniProtKB | ChEBI)
Binding site268substrate
Active site333Proton acceptor
Active site334Proton acceptor
Binding site334substrate
Binding site367Zn2+ (UniProtKB | ChEBI)
Binding site367substrate
Binding site421substrate
Binding site426Zn2+ (UniProtKB | ChEBI)
Binding site426substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionhistidinol dehydrogenase activity
Molecular FunctionNAD binding
Molecular Functionzinc ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histidinol dehydrogenase
  • EC number
  • Short names
    HDH

Gene names

    • Name
      hisD
    • ORF names
      AvCA6_12930

Organism names

  • Taxonomic identifier
  • Strain
    • CA6
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Azotobacter

Accessions

  • Primary accession
    M9YBC3

Proteomes

Subcellular Location

Family & Domains

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    436
  • Mass (Da)
    47,154
  • Last updated
    2013-06-26 v1
  • Checksum
    5670516359A6DD6E
MTTSLALRRLDAADPDFPRHLDYLLSWESVSDEAVNRRVLDILQAVRERGDAAVVEFTRRFDNVEAGSMAELILPRERLELALTRISPEQREALEKAAGRVRLYHERQKQDSWTYTEADGTVLGQQITPLDRAGLYVPGGKAAYPSSVLMNAIPAKVAGVAEVVMVVPTPRGELNELVLAAACVAGVDRVFTIGGAQAVAALAYGTESVPQVDKIVGPGNIYVATAKRHVFGQVGIDMIAGPSEILVVCDGQSDPDWIAMDLFSQAEHDEDAQSILVSPDADFLERVAESIARLLPTMERAEIIRTSLEGRGALIRVTDLEQAIAVANRIAPEHLELSVADPQRWLPKIRHAGAIFMGRYTAEALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSIIFCSAAGASELGETASVLARGESLTAHARSAEYRIKA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP005095
EMBL· GenBank· DDBJ
AGK18080.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp