M5AXY1 · RET4_FELCA

Function

function

Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.

Features

Showing features for binding site.

120120406080100120140160180200
TypeIDPosition(s)Description
Binding site116substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functionretinal binding
Molecular Functionretinol binding
Molecular Functionretinol transmembrane transporter activity
Biological Processretinol transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Retinol binding protein 4
  • Alternative names
    • Feline conceptus protein 1
      (fCP1
      )
    • Plasma retinol-binding protein
      (PRBP
      ; RBP
      )

Gene names

    • Name
      RBP4

Organism names

  • Taxonomic identifier
  • Strain
    • Abyssinian
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    M5AXY1
  • Secondary accessions
    • M3WVN1

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, modified residue.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_500406303319-201Retinol binding protein 4
Disulfide bond22↔178
Disulfide bond88↔192
Disulfide bond138↔147
Modified residue139Omega-N-methylarginine

Keywords

Proteomic databases

Expression

Tissue specificity

Highly expressed in liver. Also expressed in adipose tissue (PubMed:23719693).
Expressed by endometrium from days 16-25 and by unattached chorioallantois from days 30-36 during pregnancy (PubMed:2015342).

Developmental stage

Secreted in fetal fluids. Present on day 25, decreases from days 30-39, and disappears by day 50. Expressed by blastocysts on days 10-25 during prenatal development, but disappears by day 50.

Gene expression databases

Interaction

Subunit

Interacts with TTR. Interaction with TTR prevents its loss by filtration through the kidney glomeruli. Interacts with STRA6.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the calycin superfamily. Lipocalin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    201
  • Mass (Da)
    22,898
  • Last updated
    2013-05-29 v1
  • Checksum
    10F45F15081EE0F5
MAWVWALVLLAALGSARAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDENGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDSAKFKMKYWGVASFLQKGNDDHWIIDTDYDTYAVQYSCRLLNLDGTCADSYSFVFARDPNGLPPDVQKIVRQRQDELCLARQYRLIVHNGYCDGKSEQNIL

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A337SJC5A0A337SJC5_FELCARBP4372
A0A5F5Y0P5A0A5F5Y0P5_FELCARBP4196

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB771450
EMBL· GenBank· DDBJ
BAN13410.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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