M5AXY1 · RET4_FELCA
- ProteinRetinol binding protein 4
- GeneRBP4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids201 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 116 | substrate | ||||
Sequence: Q |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Molecular Function | retinal binding | |
Molecular Function | retinol binding | |
Molecular Function | retinol transmembrane transporter activity | |
Biological Process | retinol transport |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameRetinol binding protein 4
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionM5AXY1
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MAWVWALVLLAALGSARA | ||||||
Chain | PRO_5004063033 | 19-201 | Retinol binding protein 4 | |||
Sequence: ERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDENGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDSAKFKMKYWGVASFLQKGNDDHWIIDTDYDTYAVQYSCRLLNLDGTCADSYSFVFARDPNGLPPDVQKIVRQRQDELCLARQYRLIVHNGYCDGKSEQNIL | ||||||
Disulfide bond | 22↔178 | |||||
Sequence: CRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDENGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDSAKFKMKYWGVASFLQKGNDDHWIIDTDYDTYAVQYSCRLLNLDGTCADSYSFVFARDPNGLPPDVQKIVRQRQDELC | ||||||
Disulfide bond | 88↔192 | |||||
Sequence: CADMVGTFTDTEDSAKFKMKYWGVASFLQKGNDDHWIIDTDYDTYAVQYSCRLLNLDGTCADSYSFVFARDPNGLPPDVQKIVRQRQDELCLARQYRLIVHNGYC | ||||||
Disulfide bond | 138↔147 | |||||
Sequence: CRLLNLDGTC | ||||||
Modified residue | 139 | Omega-N-methylarginine | ||||
Sequence: R |
Keywords
- PTM
Proteomic databases
Expression
Tissue specificity
Highly expressed in liver. Also expressed in adipose tissue (PubMed:23719693).
Expressed by endometrium from days 16-25 and by unattached chorioallantois from days 30-36 during pregnancy (PubMed:2015342).
Expressed by endometrium from days 16-25 and by unattached chorioallantois from days 30-36 during pregnancy (PubMed:2015342).
Developmental stage
Secreted in fetal fluids. Present on day 25, decreases from days 30-39, and disappears by day 50. Expressed by blastocysts on days 10-25 during prenatal development, but disappears by day 50.
Gene expression databases
Interaction
Subunit
Interacts with TTR. Interaction with TTR prevents its loss by filtration through the kidney glomeruli. Interacts with STRA6.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length201
- Mass (Da)22,898
- Last updated2013-05-29 v1
- Checksum10F45F15081EE0F5
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A337SJC5 | A0A337SJC5_FELCA | RBP4 | 372 | ||
A0A5F5Y0P5 | A0A5F5Y0P5_FELCA | RBP4 | 196 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB771450 EMBL· GenBank· DDBJ | BAN13410.1 EMBL· GenBank· DDBJ | mRNA |