M4HNV6 · M4HNV6_9SAUR

Function

function

Extracellular matrix serine protease secreted by pioneer neurons that plays a role in layering of neurons in the cerebral cortex and cerebellum by coordinating cell positioning during neurodevelopment. Regulates microtubule function in neurons and neuronal migration. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcollagen-containing extracellular matrix
Cellular Componentextracellular space
Cellular Componentneuron projection
Molecular Functionhydrolase activity
Molecular Functionlipoprotein particle receptor binding
Molecular Functionmetal ion binding
Biological Processcentral nervous system development
Biological Processneuron migration

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Reelin

Gene names

    • Name
      reln

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • JFP577
    • JFP578
    • JFP579
    • JFP580
    • JFP581
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Testudinata > Testudines > Cryptodira > Durocryptodira > Testudinoidea > Emydidae > Trachemys

Accessions

  • Primary accession
    M4HNV6

Subcellular Location

Interaction

Subunit

Oligomer of disulfide-linked homodimers.

Family & Domains

Sequence similarities

Belongs to the reelin family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    49
  • Mass (Da)
    5,448
  • Last updated
    2013-05-29 v1
  • Checksum
    91552172C0C7B9C4
YAHGDSLYFNGCQIRQAITKPLDLTRASKIMFVLQIGSISQTESCNTNL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue49

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JN707437
EMBL· GenBank· DDBJ
AFR42956.1
EMBL· GenBank· DDBJ
Genomic DNA
JN707438
EMBL· GenBank· DDBJ
AFR42957.1
EMBL· GenBank· DDBJ
Genomic DNA
JN707439
EMBL· GenBank· DDBJ
AFR42958.1
EMBL· GenBank· DDBJ
Genomic DNA
JN707440
EMBL· GenBank· DDBJ
AFR42959.1
EMBL· GenBank· DDBJ
Genomic DNA
JN707441
EMBL· GenBank· DDBJ
AFR42960.1
EMBL· GenBank· DDBJ
Genomic DNA
JN707442
EMBL· GenBank· DDBJ
AFR42961.1
EMBL· GenBank· DDBJ
Genomic DNA
JN707443
EMBL· GenBank· DDBJ
AFR42962.1
EMBL· GenBank· DDBJ
Genomic DNA
JN707444
EMBL· GenBank· DDBJ
AFR42963.1
EMBL· GenBank· DDBJ
Genomic DNA
JN707445
EMBL· GenBank· DDBJ
AFR42964.1
EMBL· GenBank· DDBJ
Genomic DNA
JN707446
EMBL· GenBank· DDBJ
AFR42965.1
EMBL· GenBank· DDBJ
Genomic DNA
JN707447
EMBL· GenBank· DDBJ
AFR42966.1
EMBL· GenBank· DDBJ
Genomic DNA
JN707448
EMBL· GenBank· DDBJ
AFR42967.1
EMBL· GenBank· DDBJ
Genomic DNA
JN707465
EMBL· GenBank· DDBJ
AFR42984.1
EMBL· GenBank· DDBJ
Genomic DNA
JN707466
EMBL· GenBank· DDBJ
AFR42985.1
EMBL· GenBank· DDBJ
Genomic DNA
JN707468
EMBL· GenBank· DDBJ
AFR42987.1
EMBL· GenBank· DDBJ
Genomic DNA
JN707469
EMBL· GenBank· DDBJ
AFR42988.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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