M4HNV6 · M4HNV6_9SAUR
- ProteinReelin
- Genereln
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Extracellular matrix serine protease secreted by pioneer neurons that plays a role in layering of neurons in the cerebral cortex and cerebellum by coordinating cell positioning during neurodevelopment. Regulates microtubule function in neurons and neuronal migration. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | collagen-containing extracellular matrix | |
Cellular Component | extracellular space | |
Cellular Component | neuron projection | |
Molecular Function | hydrolase activity | |
Molecular Function | lipoprotein particle receptor binding | |
Molecular Function | metal ion binding | |
Biological Process | central nervous system development | |
Biological Process | neuron migration |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameReelin
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Testudinata > Testudines > Cryptodira > Durocryptodira > Testudinoidea > Emydidae > Trachemys
Accessions
- Primary accessionM4HNV6
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Interaction
Subunit
Oligomer of disulfide-linked homodimers.
Structure
Sequence
- Sequence statusFragment
- Length49
- Mass (Da)5,448
- Last updated2013-05-29 v1
- Checksum91552172C0C7B9C4
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: Y | ||||||
Non-terminal residue | 49 | |||||
Sequence: L |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JN707437 EMBL· GenBank· DDBJ | AFR42956.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN707438 EMBL· GenBank· DDBJ | AFR42957.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN707439 EMBL· GenBank· DDBJ | AFR42958.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN707440 EMBL· GenBank· DDBJ | AFR42959.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN707441 EMBL· GenBank· DDBJ | AFR42960.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN707442 EMBL· GenBank· DDBJ | AFR42961.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN707443 EMBL· GenBank· DDBJ | AFR42962.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN707444 EMBL· GenBank· DDBJ | AFR42963.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN707445 EMBL· GenBank· DDBJ | AFR42964.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN707446 EMBL· GenBank· DDBJ | AFR42965.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN707447 EMBL· GenBank· DDBJ | AFR42966.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN707448 EMBL· GenBank· DDBJ | AFR42967.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN707465 EMBL· GenBank· DDBJ | AFR42984.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN707466 EMBL· GenBank· DDBJ | AFR42985.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN707468 EMBL· GenBank· DDBJ | AFR42987.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN707469 EMBL· GenBank· DDBJ | AFR42988.1 EMBL· GenBank· DDBJ | Genomic DNA |