M1G5Z3 · M1G5Z3_MERBI

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Zeiogadaria > Gadariae > Gadiformes > Gadoidei > Merlucciidae > Merluccius

Accessions

  • Primary accession
    M1G5Z3

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-24Helical
Transmembrane36-58Helical
Transmembrane92-112Helical
Transmembrane132-154Helical
Transmembrane166-193Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-217Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    217
  • Mass (Da)
    23,135
  • Last updated
    2013-05-01 v1
  • Checksum
    A98A96D1FEF62821
LYLVFGAWAGMVGTALSLLIRAELSQPGALLGDDQIYNVIVTAHAFVMIFFMVMPLMIGGFGNWLIPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLASNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAISQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTSFFDPAGGGDPILYQHL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue217

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC015665
EMBL· GenBank· DDBJ
AFZ76154.1
EMBL· GenBank· DDBJ
Genomic DNA
KC015666
EMBL· GenBank· DDBJ
AFZ76155.1
EMBL· GenBank· DDBJ
Genomic DNA
KC015667
EMBL· GenBank· DDBJ
AFZ76156.1
EMBL· GenBank· DDBJ
Genomic DNA
KC015668
EMBL· GenBank· DDBJ
AFZ76157.1
EMBL· GenBank· DDBJ
Genomic DNA
KC015669
EMBL· GenBank· DDBJ
AFZ76158.1
EMBL· GenBank· DDBJ
Genomic DNA
KC015671
EMBL· GenBank· DDBJ
AFZ76160.1
EMBL· GenBank· DDBJ
Genomic DNA
KC015672
EMBL· GenBank· DDBJ
AFZ76161.1
EMBL· GenBank· DDBJ
Genomic DNA
KC015673
EMBL· GenBank· DDBJ
AFZ76162.1
EMBL· GenBank· DDBJ
Genomic DNA
KC015675
EMBL· GenBank· DDBJ
AFZ76164.1
EMBL· GenBank· DDBJ
Genomic DNA
KC015677
EMBL· GenBank· DDBJ
AFZ76166.1
EMBL· GenBank· DDBJ
Genomic DNA
KC015678
EMBL· GenBank· DDBJ
AFZ76167.1
EMBL· GenBank· DDBJ
Genomic DNA
KC015679
EMBL· GenBank· DDBJ
AFZ76168.1
EMBL· GenBank· DDBJ
Genomic DNA
KC015681
EMBL· GenBank· DDBJ
AFZ76170.1
EMBL· GenBank· DDBJ
Genomic DNA
KC015682
EMBL· GenBank· DDBJ
AFZ76171.1
EMBL· GenBank· DDBJ
Genomic DNA
KC015683
EMBL· GenBank· DDBJ
AFZ76172.1
EMBL· GenBank· DDBJ
Genomic DNA
KC015684
EMBL· GenBank· DDBJ
AFZ76173.1
EMBL· GenBank· DDBJ
Genomic DNA
KC015685
EMBL· GenBank· DDBJ
AFZ76174.1
EMBL· GenBank· DDBJ
Genomic DNA
KF930126
EMBL· GenBank· DDBJ
AHI87065.1
EMBL· GenBank· DDBJ
Genomic DNA
KF930127
EMBL· GenBank· DDBJ
AHI87066.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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