L7NCR1 · NLP6_PHYCP

  • Protein
    NLP effector protein 6
  • Gene
    NLP6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Secreted effector that contributes strongly to virulence during infection by P.capsici. Causes large necrotic areas in both host C.annuum and non-host N.benthamiana.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    NLP effector protein 6
  • Alternative names
    • Necrosis-inducing protein 6
    • Nep1-like protein 6

Gene names

    • Name
      NLP6
    • Synonyms
      NPP6

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Sar > Stramenopiles > Oomycota > Peronosporales > Peronosporaceae > Phytophthora

Accessions

  • Primary accession
    L7NCR1

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_500398251020-338NLP effector protein 6
Glycosylation81N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Expression

Induction

Expression reached the highest levels at 3 days after inoculation of pepper leaves, followed by a gradual decline.

Structure

Family & Domains

Features

Showing features for region, compositional bias, motif.

TypeIDPosition(s)Description
Region68-119Disordered
Compositional bias69-83Polar residues
Compositional bias97-117Pro residues
Motif205-215Conserved undecapeptide motif I
Motif222-227Hepta-peptide GHRHDWE motif II

Domain

Key residues/motif important for the effector activities are degenerated in most NLPs, including the nlp24 peptide consisting of the conserved region I (11-aa immunogenic part) and conserved region II (the heptapeptide GHRHDWE motif) that is important for phytotoxic activity.

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    338
  • Mass (Da)
    37,326
  • Last updated
    2013-04-03 v1
  • Checksum
    F9A91B6B7C1C082D
MRFTTIFWISLTVLATVRAEDGSHAQNEVQAGDGSHVQNEVQVGSEPQTQDSIETPKPTIKYIDFGDLTLSPSASSPAKRNVTLPPDTTMRPDPRQTEPPTEAPTPASTPAPTPDPGPWVDKWIGHDQVKPFPQPEPVTISEKAGVKFKPQIQIRTGCEPYPAVNEYGETGGGLKTTGKSRGNCGGSGYGSQVYGRSTWIRGVWAIMYSWYFPKDSPSPKMGHRHDWEHAIVFIDNPEVSEPKILACSVSSHDGYKKYNPCPSWVIDGTSLKVRYKHAWPLNHDLDATGDGGKFQDSIMWNQLTEDARRALNSVSFGKANTPFNDGKFMPKIENAWPF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias69-83Polar residues
Compositional bias97-117Pro residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HM543172
EMBL· GenBank· DDBJ
AEJ88237.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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