J7Q6V7 · J7Q6V7_METSZ

Function

function

Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site87S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site109S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site129S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site137S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionRNA binding
Molecular FunctiontRNA (5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase activity
Molecular FunctiontRNA (cytidine(34)-2'-O)-methyltransferase activity
Biological Processwobble position cytosine ribose methylation
Biological Processwobble position uridine ribose methylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA (cytidine(34)-2'-O)-methyltransferase
  • EC number
  • Alternative names
    • tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL

Gene names

    • Name
      trmL
    • Ordered locus names
      BN69_0096

Organism names

  • Taxonomic identifier
  • Strain
    • SC2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Methylocystaceae > Methylocystis

Accessions

  • Primary accession
    J7Q6V7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-148tRNA/rRNA methyltransferase SpoU type

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    158
  • Mass (Da)
    16,888
  • Last updated
    2012-10-31 v1
  • Checksum
    E19D0B65E6618AB9
MTSLTLALYQPDIPQNAGAMLRTCACLGVSAAIIGPAGFPTSDRDFRRAGMDYLDHVTIDRHGSFAAFQAWRAASGQAGESRRLLLLSTRAAGSYLDCDYRAGDILLVGRESAGAPEEVHAAADLALRIPMRPRMRSLNVAVAAAMVMGEALRQLRAL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HE956757
EMBL· GenBank· DDBJ
CCJ05547.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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